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Anion mediated, tunable isoguanosine self-assemblies: decoding the conformation influence and solvent effects
Systematic investigations were performed with various substituted groups at C8 purine and ribose. A series of isoG analogs, C8-phenyl substituted isoG were synthesized and applied for Cs(+) coordination. The structural proximity between purine and ribose limited pentaplex formation for C8-phenyl sub...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171338/ https://www.ncbi.nlm.nih.gov/pubmed/34163848 http://dx.doi.org/10.1039/d1sc00988e |
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author | Liu, Mengjia He, Ying Shan, Chuan Wojtas, Lukasz Ghiviriga, Ion Fathalla, Omar Yan, Yu Li, Xiaopeng Shi, Xiaodong |
author_facet | Liu, Mengjia He, Ying Shan, Chuan Wojtas, Lukasz Ghiviriga, Ion Fathalla, Omar Yan, Yu Li, Xiaopeng Shi, Xiaodong |
author_sort | Liu, Mengjia |
collection | PubMed |
description | Systematic investigations were performed with various substituted groups at C8 purine and ribose. A series of isoG analogs, C8-phenyl substituted isoG were synthesized and applied for Cs(+) coordination. The structural proximity between purine and ribose limited pentaplex formation for C8-phenyl substituted isoG derivatives. Based on this observation, deoxy isoG derivative with modification on ribose (tert-butyldimethylsilyl ether) was applied to assemble with the Cs(+) cation. Critical solvent (CDCl(3) and CD(3)CN) and anion (BPh(4)(−), BARF(−), and PF(6)(−)) effects were revealed, leading to the controllable formation of various stable isoG pentaplexes, including singly charged decamer, doubly charged decamer, and 15-mer, etc. Finally, the X-ray crystal structure of [isoG(20)Cs(3)](3+)(BARF(−))(3) was successfully obtained, which is the first example of multiple-layer deoxy isoG binding with the Cs(+) cation, providing solid evidence of this new isoG ionophore beyond two-layer sandwich self-assembly. |
format | Online Article Text |
id | pubmed-8171338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-81713382021-06-22 Anion mediated, tunable isoguanosine self-assemblies: decoding the conformation influence and solvent effects Liu, Mengjia He, Ying Shan, Chuan Wojtas, Lukasz Ghiviriga, Ion Fathalla, Omar Yan, Yu Li, Xiaopeng Shi, Xiaodong Chem Sci Chemistry Systematic investigations were performed with various substituted groups at C8 purine and ribose. A series of isoG analogs, C8-phenyl substituted isoG were synthesized and applied for Cs(+) coordination. The structural proximity between purine and ribose limited pentaplex formation for C8-phenyl substituted isoG derivatives. Based on this observation, deoxy isoG derivative with modification on ribose (tert-butyldimethylsilyl ether) was applied to assemble with the Cs(+) cation. Critical solvent (CDCl(3) and CD(3)CN) and anion (BPh(4)(−), BARF(−), and PF(6)(−)) effects were revealed, leading to the controllable formation of various stable isoG pentaplexes, including singly charged decamer, doubly charged decamer, and 15-mer, etc. Finally, the X-ray crystal structure of [isoG(20)Cs(3)](3+)(BARF(−))(3) was successfully obtained, which is the first example of multiple-layer deoxy isoG binding with the Cs(+) cation, providing solid evidence of this new isoG ionophore beyond two-layer sandwich self-assembly. The Royal Society of Chemistry 2021-04-26 /pmc/articles/PMC8171338/ /pubmed/34163848 http://dx.doi.org/10.1039/d1sc00988e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Liu, Mengjia He, Ying Shan, Chuan Wojtas, Lukasz Ghiviriga, Ion Fathalla, Omar Yan, Yu Li, Xiaopeng Shi, Xiaodong Anion mediated, tunable isoguanosine self-assemblies: decoding the conformation influence and solvent effects |
title | Anion mediated, tunable isoguanosine self-assemblies: decoding the conformation influence and solvent effects |
title_full | Anion mediated, tunable isoguanosine self-assemblies: decoding the conformation influence and solvent effects |
title_fullStr | Anion mediated, tunable isoguanosine self-assemblies: decoding the conformation influence and solvent effects |
title_full_unstemmed | Anion mediated, tunable isoguanosine self-assemblies: decoding the conformation influence and solvent effects |
title_short | Anion mediated, tunable isoguanosine self-assemblies: decoding the conformation influence and solvent effects |
title_sort | anion mediated, tunable isoguanosine self-assemblies: decoding the conformation influence and solvent effects |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171338/ https://www.ncbi.nlm.nih.gov/pubmed/34163848 http://dx.doi.org/10.1039/d1sc00988e |
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