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Observation of liquid–liquid phase separation of ataxin-3 and quantitative evaluation of its concentration in a single droplet using Raman microscopy

Liquid–liquid phase separation (LLPS) plays an important role in a variety of biological processes and is also associated with protein aggregation in neurodegenerative diseases. Quantification of LLPS is necessary to elucidate the mechanism of LLPS and the subsequent aggregation process. In this stu...

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Detalles Bibliográficos
Autores principales:	Murakami, Kazuki, Kajimoto, Shinji, Shibata, Daiki, Kuroi, Kunisato, Fujii, Fumihiko, Nakabayashi, Takakazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171347/ https://www.ncbi.nlm.nih.gov/pubmed/34163831 http://dx.doi.org/10.1039/d0sc06095j

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