Functional Consequences of Mutations in Myeloproliferative Neoplasms

Driver mutations occur in Janus kinase 2 (JAK2), thrombopoietin receptor (MPL), and calreticulin (CALR) in BCR-ABL1 negative myeloproliferative neoplasms (MPNs). From mutations leading to one amino acid substitution in JAK2 or MPL, to frameshift mutations in CALR resulting in a protein with a differ...

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Detalles Bibliográficos
Autores principales: Constantinescu, Stefan N., Vainchenker, William, Levy, Gabriel, Papadopoulos, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171364/
https://www.ncbi.nlm.nih.gov/pubmed/34095761
http://dx.doi.org/10.1097/HS9.0000000000000578

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