Cargando…

Significant elevation of aqueous endothelin-1 in central retinal vein occlusion

PURPOSE: To investigate aqueous humor concentrations of endothelin-1 (ET-1) in patients with central retinal vein occlusion (CRVO) compared with patients with branch retinal vein occlusion (BRVO) and a normal control group. METHODS: A total 80 subjects were included in this prospective study, includ...

Descripción completa

Detalles Bibliográficos
Autores principales: Kang, Hae Min, Hasanuzzaman, Md., Kim, So Won, Koh, Hyoung Jun, Lee, Sung Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171894/
https://www.ncbi.nlm.nih.gov/pubmed/34077461
http://dx.doi.org/10.1371/journal.pone.0252530
_version_ 1783702443160240128
author Kang, Hae Min
Hasanuzzaman, Md.
Kim, So Won
Koh, Hyoung Jun
Lee, Sung Chul
author_facet Kang, Hae Min
Hasanuzzaman, Md.
Kim, So Won
Koh, Hyoung Jun
Lee, Sung Chul
author_sort Kang, Hae Min
collection PubMed
description PURPOSE: To investigate aqueous humor concentrations of endothelin-1 (ET-1) in patients with central retinal vein occlusion (CRVO) compared with patients with branch retinal vein occlusion (BRVO) and a normal control group. METHODS: A total 80 subjects were included in this prospective study, including 15 patients with CRVO, 20 patients with BRVO, and 45 patients who underwent cataract surgery and had no concomitant ocular disease. Aqueous humor levels of ET-1 were obtained before intravitreal bevacizumab injection (IVB) and after 1 month. RESULTS: At baseline, the mean aqueous ET-1 level was 12.7±3.6 pg/mL in the CRVO group, 8.0±2.3 pg/mL in the BRVO group, and 2.0±0.9 pg/mL in the control group (P<0.001). After IVB, the mean aqueous level of ET-1 was 3.4±1.9 pg/mL (0.5–6.9 pg/mL) in the CRVO group and 1.8±1.0 pg/mL (0.3–3.2 pg/mL) in the BRVO group (P = 0.008). The mean aqueous ET-1 level was significantly reduced in both the patients with CRVO and those with BRVO (P<0.001). CONCLUSION: The mean aqueous humor ET-1 level was significant higher in the patients with CRVO than those with BRVO and in the control group. After IVB, the mean level was significantly reduced in both the patients with CRVO and those with BRVO.
format Online
Article
Text
id pubmed-8171894
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-81718942021-06-14 Significant elevation of aqueous endothelin-1 in central retinal vein occlusion Kang, Hae Min Hasanuzzaman, Md. Kim, So Won Koh, Hyoung Jun Lee, Sung Chul PLoS One Research Article PURPOSE: To investigate aqueous humor concentrations of endothelin-1 (ET-1) in patients with central retinal vein occlusion (CRVO) compared with patients with branch retinal vein occlusion (BRVO) and a normal control group. METHODS: A total 80 subjects were included in this prospective study, including 15 patients with CRVO, 20 patients with BRVO, and 45 patients who underwent cataract surgery and had no concomitant ocular disease. Aqueous humor levels of ET-1 were obtained before intravitreal bevacizumab injection (IVB) and after 1 month. RESULTS: At baseline, the mean aqueous ET-1 level was 12.7±3.6 pg/mL in the CRVO group, 8.0±2.3 pg/mL in the BRVO group, and 2.0±0.9 pg/mL in the control group (P<0.001). After IVB, the mean aqueous level of ET-1 was 3.4±1.9 pg/mL (0.5–6.9 pg/mL) in the CRVO group and 1.8±1.0 pg/mL (0.3–3.2 pg/mL) in the BRVO group (P = 0.008). The mean aqueous ET-1 level was significantly reduced in both the patients with CRVO and those with BRVO (P<0.001). CONCLUSION: The mean aqueous humor ET-1 level was significant higher in the patients with CRVO than those with BRVO and in the control group. After IVB, the mean level was significantly reduced in both the patients with CRVO and those with BRVO. Public Library of Science 2021-06-02 /pmc/articles/PMC8171894/ /pubmed/34077461 http://dx.doi.org/10.1371/journal.pone.0252530 Text en © 2021 Kang et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kang, Hae Min
Hasanuzzaman, Md.
Kim, So Won
Koh, Hyoung Jun
Lee, Sung Chul
Significant elevation of aqueous endothelin-1 in central retinal vein occlusion
title Significant elevation of aqueous endothelin-1 in central retinal vein occlusion
title_full Significant elevation of aqueous endothelin-1 in central retinal vein occlusion
title_fullStr Significant elevation of aqueous endothelin-1 in central retinal vein occlusion
title_full_unstemmed Significant elevation of aqueous endothelin-1 in central retinal vein occlusion
title_short Significant elevation of aqueous endothelin-1 in central retinal vein occlusion
title_sort significant elevation of aqueous endothelin-1 in central retinal vein occlusion
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171894/
https://www.ncbi.nlm.nih.gov/pubmed/34077461
http://dx.doi.org/10.1371/journal.pone.0252530
work_keys_str_mv AT kanghaemin significantelevationofaqueousendothelin1incentralretinalveinocclusion
AT hasanuzzamanmd significantelevationofaqueousendothelin1incentralretinalveinocclusion
AT kimsowon significantelevationofaqueousendothelin1incentralretinalveinocclusion
AT kohhyoungjun significantelevationofaqueousendothelin1incentralretinalveinocclusion
AT leesungchul significantelevationofaqueousendothelin1incentralretinalveinocclusion