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Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial
BACKGROUND: Acne vulgaris is a common inflammatory disease of the pilosebaceous follicle that affects many teenagers and young people. There is an obvious need for topical treatments with good tolerability and efficacy for the management of acne lesions. OBJECTIVE: This study determined the therapeu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mattioli 1885
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172071/ https://www.ncbi.nlm.nih.gov/pubmed/34123555 http://dx.doi.org/10.5826/dpc.1103a46 |
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author | Dorostkar, Azadeh Ghahartars, Mehdi Namazi, Mohammadreza Todarbary, Nafiseh Hadibarhaghtalab, Maryam Rezaee, Maryam |
author_facet | Dorostkar, Azadeh Ghahartars, Mehdi Namazi, Mohammadreza Todarbary, Nafiseh Hadibarhaghtalab, Maryam Rezaee, Maryam |
author_sort | Dorostkar, Azadeh |
collection | PubMed |
description | BACKGROUND: Acne vulgaris is a common inflammatory disease of the pilosebaceous follicle that affects many teenagers and young people. There is an obvious need for topical treatments with good tolerability and efficacy for the management of acne lesions. OBJECTIVE: This study determined the therapeutic efficacy of topical sodium hypochlorite solution (0.005%) in the treatment of mild to moderate acne lesions. METHODS: This placebo-controlled randomized controlled trial compared 0.005% sodium hypochlorite to placebo administered topically on each side of the patients’ faces 3 times a day for 1 month. The numbers of papules and pustules were recorded at baseline, 1, 2 and 4 weeks after initiation. RESULTS: The total number of papules and pustules decreased after topical application of sodium hypochlorite 0.005% for 1 month. CONCLUSIONS: Topical sodium hypochlorite solution (0.005%) can be effective in the treatment of mild to moderate acne, and its clinical efficacy was evaluated between the male and female groups and between the hormonal and non-hormonal ones. TRIAL REGISTRATION: Our study was registered in the Iranian Registry of Clinical Trials (IRCT) with the code number IRCT20200701047976N1. |
format | Online Article Text |
id | pubmed-8172071 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Mattioli 1885 |
record_format | MEDLINE/PubMed |
spelling | pubmed-81720712021-06-11 Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial Dorostkar, Azadeh Ghahartars, Mehdi Namazi, Mohammadreza Todarbary, Nafiseh Hadibarhaghtalab, Maryam Rezaee, Maryam Dermatol Pract Concept Research BACKGROUND: Acne vulgaris is a common inflammatory disease of the pilosebaceous follicle that affects many teenagers and young people. There is an obvious need for topical treatments with good tolerability and efficacy for the management of acne lesions. OBJECTIVE: This study determined the therapeutic efficacy of topical sodium hypochlorite solution (0.005%) in the treatment of mild to moderate acne lesions. METHODS: This placebo-controlled randomized controlled trial compared 0.005% sodium hypochlorite to placebo administered topically on each side of the patients’ faces 3 times a day for 1 month. The numbers of papules and pustules were recorded at baseline, 1, 2 and 4 weeks after initiation. RESULTS: The total number of papules and pustules decreased after topical application of sodium hypochlorite 0.005% for 1 month. CONCLUSIONS: Topical sodium hypochlorite solution (0.005%) can be effective in the treatment of mild to moderate acne, and its clinical efficacy was evaluated between the male and female groups and between the hormonal and non-hormonal ones. TRIAL REGISTRATION: Our study was registered in the Iranian Registry of Clinical Trials (IRCT) with the code number IRCT20200701047976N1. Mattioli 1885 2021-05-20 /pmc/articles/PMC8172071/ /pubmed/34123555 http://dx.doi.org/10.5826/dpc.1103a46 Text en ©2021 Dorostkar et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License BY-NC-4.0, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited. |
spellingShingle | Research Dorostkar, Azadeh Ghahartars, Mehdi Namazi, Mohammadreza Todarbary, Nafiseh Hadibarhaghtalab, Maryam Rezaee, Maryam Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial |
title | Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial |
title_full | Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial |
title_fullStr | Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial |
title_full_unstemmed | Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial |
title_short | Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial |
title_sort | sodium hypochlorite 0.005% versus placebo in the treatment of mild to moderate acne: a double-blind randomized controlled trial |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172071/ https://www.ncbi.nlm.nih.gov/pubmed/34123555 http://dx.doi.org/10.5826/dpc.1103a46 |
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