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Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations
Achieving strong adhesion of bioadhesives on wet tissues remains a challenge and an acute clinical demand because of the interfering interfacial water and limited adhesive-tissue interactions. Here we report a self-gelling and adhesive polyethyleneimine and polyacrylic acid (PEI/PAA) powder, which c...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172133/ https://www.ncbi.nlm.nih.gov/pubmed/34078598 http://dx.doi.org/10.1126/sciadv.abe8739 |
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author | Peng, Xin Xia, Xianfeng Xu, Xiayi Yang, Xuefeng Yang, Boguang Zhao, Pengchao Yuan, Weihao Chiu, Philip Wai Yan Bian, Liming |
author_facet | Peng, Xin Xia, Xianfeng Xu, Xiayi Yang, Xuefeng Yang, Boguang Zhao, Pengchao Yuan, Weihao Chiu, Philip Wai Yan Bian, Liming |
author_sort | Peng, Xin |
collection | PubMed |
description | Achieving strong adhesion of bioadhesives on wet tissues remains a challenge and an acute clinical demand because of the interfering interfacial water and limited adhesive-tissue interactions. Here we report a self-gelling and adhesive polyethyleneimine and polyacrylic acid (PEI/PAA) powder, which can absorb interfacial water to form a physically cross-linked hydrogel in situ within 2 seconds due to strong physical interactions between the polymers. Furthermore, the physically cross-linked polymers can diffuse into the substrate polymeric network to enhance wet adhesion. Superficial deposition of PEI/PAA powder can effectively seal damaged porcine stomach and intestine despite excessive mechanical challenges and tissue surface irregularities. We further demonstrate PEI/PAA powder as an effective sealant to enhance the treatment outcomes of gastric perforation in a rat model. The strong wet adhesion, excellent cytocompatibility, adaptability to fit complex sites, and easy synthesis of PEI/PAA powder make it a promising bioadhesive for numerous biomedical applications. |
format | Online Article Text |
id | pubmed-8172133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-81721332021-06-10 Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations Peng, Xin Xia, Xianfeng Xu, Xiayi Yang, Xuefeng Yang, Boguang Zhao, Pengchao Yuan, Weihao Chiu, Philip Wai Yan Bian, Liming Sci Adv Research Articles Achieving strong adhesion of bioadhesives on wet tissues remains a challenge and an acute clinical demand because of the interfering interfacial water and limited adhesive-tissue interactions. Here we report a self-gelling and adhesive polyethyleneimine and polyacrylic acid (PEI/PAA) powder, which can absorb interfacial water to form a physically cross-linked hydrogel in situ within 2 seconds due to strong physical interactions between the polymers. Furthermore, the physically cross-linked polymers can diffuse into the substrate polymeric network to enhance wet adhesion. Superficial deposition of PEI/PAA powder can effectively seal damaged porcine stomach and intestine despite excessive mechanical challenges and tissue surface irregularities. We further demonstrate PEI/PAA powder as an effective sealant to enhance the treatment outcomes of gastric perforation in a rat model. The strong wet adhesion, excellent cytocompatibility, adaptability to fit complex sites, and easy synthesis of PEI/PAA powder make it a promising bioadhesive for numerous biomedical applications. American Association for the Advancement of Science 2021-06-02 /pmc/articles/PMC8172133/ /pubmed/34078598 http://dx.doi.org/10.1126/sciadv.abe8739 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Peng, Xin Xia, Xianfeng Xu, Xiayi Yang, Xuefeng Yang, Boguang Zhao, Pengchao Yuan, Weihao Chiu, Philip Wai Yan Bian, Liming Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations |
title | Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations |
title_full | Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations |
title_fullStr | Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations |
title_full_unstemmed | Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations |
title_short | Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations |
title_sort | ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172133/ https://www.ncbi.nlm.nih.gov/pubmed/34078598 http://dx.doi.org/10.1126/sciadv.abe8739 |
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