Fibrinogen-mimicking, multiarm nanovesicles for human thrombus-specific delivery of tissue plasminogen activator and targeted thrombolytic therapy

Clinical use of tissue plasminogen activator (tPA) in thrombolytic therapy is limited by its short circulation time and hemorrhagic side effects. Inspired by fibrinogen binding to activated platelets, we report a fibrinogen-mimicking, multiarm nanovesicle for thrombus-specific tPA delivery and targe...

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Detalles Bibliográficos
Autores principales: Huang, Yu, Gu, Boram, Salles-Crawley, Isabelle I., Taylor, Kirk A., Yu, Li, Ren, Jie, Liu, Xuhan, Emerson, Michael, Longstaff, Colin, Hughes, Alun D., Thom, Simon A., Xu, Xiao Yun, Chen, Rongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172176/
https://www.ncbi.nlm.nih.gov/pubmed/34078604
http://dx.doi.org/10.1126/sciadv.abf9033

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