UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation

The formation of hyperphosphorylated intracellular Tau tangles in the brain is a hallmark of Alzheimer’s disease (AD). Tau hyperphosphorylation destabilizes microtubules, promoting neurodegeneration in AD patients. To identify suppressors of tau-mediated AD, we perform a screen using a microRNA (miR...

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Detalles Bibliográficos
Autores principales: Subramanian, Manivannan, Hyeon, Seung Jae, Das, Tanuza, Suh, Yoon Seok, Kim, Yun Kyung, Lee, Jeong-Soo, Song, Eun Joo, Ryu, Hoon, Yu, Kweon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172564/
https://www.ncbi.nlm.nih.gov/pubmed/34078905
http://dx.doi.org/10.1038/s41467-021-23597-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172564/
https://www.ncbi.nlm.nih.gov/pubmed/34078905
http://dx.doi.org/10.1038/s41467-021-23597-9

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