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Comparison between male and female breast cancer survival using propensity score matching analysis
Male breast cancer (MBC) is a rare disease. The few studies on MBC reported conflicting data regarding survival outcomes compared to women. This study has two objectives: to describe the characteristics of a single-cohort of MBC and to compare overall survival (OS) and disease-free survival (DFS) be...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172634/ https://www.ncbi.nlm.nih.gov/pubmed/34079019 http://dx.doi.org/10.1038/s41598-021-91131-4 |
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author | Scomersi, Serena Giudici, Fabiola Cacciatore, Giuseppe Losurdo, Pasquale Fracon, Stefano Cortinovis, Sara Ceccherini, Rita Zanconati, Fabrizio Tonutti, Maura Bortul, Marina |
author_facet | Scomersi, Serena Giudici, Fabiola Cacciatore, Giuseppe Losurdo, Pasquale Fracon, Stefano Cortinovis, Sara Ceccherini, Rita Zanconati, Fabrizio Tonutti, Maura Bortul, Marina |
author_sort | Scomersi, Serena |
collection | PubMed |
description | Male breast cancer (MBC) is a rare disease. The few studies on MBC reported conflicting data regarding survival outcomes compared to women. This study has two objectives: to describe the characteristics of a single-cohort of MBC and to compare overall survival (OS) and disease-free survival (DFS) between men and women using the propensity score matching (PSM) analysis. We considered MBC patients (n = 40) diagnosed between January 2004 and May 2019. Clinical, pathological, oncological and follow-up data were analyzed. Univariate analysis was performed to determine the prognostic factors on OS and DFS for MBC. We selected female patients with BC (n = 2678). To minimize the effect of the imbalance of the prognostic factors between the two cohorts, the PSM method (1:3 ratio) was applied and differences in survival between the two groups were assessed. The average age of MBC patients was 73 years. The 5-year OS and DFS rates were 76.7% and 72.2% respectively. The prognostic factors that significantly influenced OS and DFS were tumor size and lymph node status. After the PSM, 5 year-OS was similar between MBC and FBC (72.9% vs 72.3%, p = 0.70) while we found a worse DFS for MBC (72.2% vs 91.4%, p = 0.03). Our data confirmed previous reported MBC characteristics: we found a higher risk of recurrence in MBC compared to FMC but similar OS. MBC and FMC are different entities and studies are needed to understand its epidemiology and guide its management. |
format | Online Article Text |
id | pubmed-8172634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-81726342021-06-03 Comparison between male and female breast cancer survival using propensity score matching analysis Scomersi, Serena Giudici, Fabiola Cacciatore, Giuseppe Losurdo, Pasquale Fracon, Stefano Cortinovis, Sara Ceccherini, Rita Zanconati, Fabrizio Tonutti, Maura Bortul, Marina Sci Rep Article Male breast cancer (MBC) is a rare disease. The few studies on MBC reported conflicting data regarding survival outcomes compared to women. This study has two objectives: to describe the characteristics of a single-cohort of MBC and to compare overall survival (OS) and disease-free survival (DFS) between men and women using the propensity score matching (PSM) analysis. We considered MBC patients (n = 40) diagnosed between January 2004 and May 2019. Clinical, pathological, oncological and follow-up data were analyzed. Univariate analysis was performed to determine the prognostic factors on OS and DFS for MBC. We selected female patients with BC (n = 2678). To minimize the effect of the imbalance of the prognostic factors between the two cohorts, the PSM method (1:3 ratio) was applied and differences in survival between the two groups were assessed. The average age of MBC patients was 73 years. The 5-year OS and DFS rates were 76.7% and 72.2% respectively. The prognostic factors that significantly influenced OS and DFS were tumor size and lymph node status. After the PSM, 5 year-OS was similar between MBC and FBC (72.9% vs 72.3%, p = 0.70) while we found a worse DFS for MBC (72.2% vs 91.4%, p = 0.03). Our data confirmed previous reported MBC characteristics: we found a higher risk of recurrence in MBC compared to FMC but similar OS. MBC and FMC are different entities and studies are needed to understand its epidemiology and guide its management. Nature Publishing Group UK 2021-06-02 /pmc/articles/PMC8172634/ /pubmed/34079019 http://dx.doi.org/10.1038/s41598-021-91131-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Scomersi, Serena Giudici, Fabiola Cacciatore, Giuseppe Losurdo, Pasquale Fracon, Stefano Cortinovis, Sara Ceccherini, Rita Zanconati, Fabrizio Tonutti, Maura Bortul, Marina Comparison between male and female breast cancer survival using propensity score matching analysis |
title | Comparison between male and female breast cancer survival using propensity score matching analysis |
title_full | Comparison between male and female breast cancer survival using propensity score matching analysis |
title_fullStr | Comparison between male and female breast cancer survival using propensity score matching analysis |
title_full_unstemmed | Comparison between male and female breast cancer survival using propensity score matching analysis |
title_short | Comparison between male and female breast cancer survival using propensity score matching analysis |
title_sort | comparison between male and female breast cancer survival using propensity score matching analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172634/ https://www.ncbi.nlm.nih.gov/pubmed/34079019 http://dx.doi.org/10.1038/s41598-021-91131-4 |
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