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Pharyngeal spreading of peri-implant infections under antiresorptive/antiangiogenic therapy
OBJECTIVES: To assess the influence of antiresorptive/antiangiogenic therapy on the spreading of peri-implant infections in the pharyngeal region. MATERIAL AND METHODS: This analysis was based on tissue biopsies obtained from a total of twenty-five albino rats having either received (1) amino-bispho...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172650/ https://www.ncbi.nlm.nih.gov/pubmed/34080056 http://dx.doi.org/10.1186/s40729-021-00332-z |
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author | Kern, Karsten Lukmann, Fania Obreja, Karina Al-Maawi, Sara Carla, Bellinghausen Ghanaati, Shahram Rohde, Gernot Sader, Robert Schwarz, Frank |
author_facet | Kern, Karsten Lukmann, Fania Obreja, Karina Al-Maawi, Sara Carla, Bellinghausen Ghanaati, Shahram Rohde, Gernot Sader, Robert Schwarz, Frank |
author_sort | Kern, Karsten |
collection | PubMed |
description | OBJECTIVES: To assess the influence of antiresorptive/antiangiogenic therapy on the spreading of peri-implant infections in the pharyngeal region. MATERIAL AND METHODS: This analysis was based on tissue biopsies obtained from a total of twenty-five albino rats having either received (1) amino-bisphosphonate (Zoledronate) (Zo) (n=4), (2) RANKL inhibitor (Denosumab) (De) (n=4), (3) antiangiogenic medication (Bevacizumab) (Be) (n=4), (4) Zo+Be (n=3), (5) De+Be (n=5), or (6) no medication (Co) (n=5). Drug administration was repeated at 12 weeks. Chronic-type peri-implant infections were induced at titanium implants located in the upper jaws. The surface area (%) of infiltrated connective tissue (ICT) and CD68-positive cells was assessed within the lateral pharyngeal/retropharyngeal connective tissue zone. RESULTS: Mean (±SD) and median ICT% values and CD68 counts were markedly highest in the De+Be (11.10±6.04; 11.81; 95% CI − 3.89; 26.11) and De (5.70±5.06; 6.19; 95% CI − 2.34; 13.75) groups, reaching statistical significance for De CD68 counts over the Co (0.18±0.25; 0.18; 95% CI −2.14; 2.51) group. In both De+Be and De groups, the ICTs were occasionally associated with an ulceration of the epithelial compartment. CONCLUSIONS: Induced peri-implant infections were not associated with any inflammatory lesions in pharyngeal tissues. While these findings were similar under Zo and Be medication, De and De+Be had a marked effect on ICT and CD68 values. The clinical relevance of these adverse findings needs further investigation. |
format | Online Article Text |
id | pubmed-8172650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-81726502021-06-17 Pharyngeal spreading of peri-implant infections under antiresorptive/antiangiogenic therapy Kern, Karsten Lukmann, Fania Obreja, Karina Al-Maawi, Sara Carla, Bellinghausen Ghanaati, Shahram Rohde, Gernot Sader, Robert Schwarz, Frank Int J Implant Dent Research OBJECTIVES: To assess the influence of antiresorptive/antiangiogenic therapy on the spreading of peri-implant infections in the pharyngeal region. MATERIAL AND METHODS: This analysis was based on tissue biopsies obtained from a total of twenty-five albino rats having either received (1) amino-bisphosphonate (Zoledronate) (Zo) (n=4), (2) RANKL inhibitor (Denosumab) (De) (n=4), (3) antiangiogenic medication (Bevacizumab) (Be) (n=4), (4) Zo+Be (n=3), (5) De+Be (n=5), or (6) no medication (Co) (n=5). Drug administration was repeated at 12 weeks. Chronic-type peri-implant infections were induced at titanium implants located in the upper jaws. The surface area (%) of infiltrated connective tissue (ICT) and CD68-positive cells was assessed within the lateral pharyngeal/retropharyngeal connective tissue zone. RESULTS: Mean (±SD) and median ICT% values and CD68 counts were markedly highest in the De+Be (11.10±6.04; 11.81; 95% CI − 3.89; 26.11) and De (5.70±5.06; 6.19; 95% CI − 2.34; 13.75) groups, reaching statistical significance for De CD68 counts over the Co (0.18±0.25; 0.18; 95% CI −2.14; 2.51) group. In both De+Be and De groups, the ICTs were occasionally associated with an ulceration of the epithelial compartment. CONCLUSIONS: Induced peri-implant infections were not associated with any inflammatory lesions in pharyngeal tissues. While these findings were similar under Zo and Be medication, De and De+Be had a marked effect on ICT and CD68 values. The clinical relevance of these adverse findings needs further investigation. Springer Berlin Heidelberg 2021-06-03 /pmc/articles/PMC8172650/ /pubmed/34080056 http://dx.doi.org/10.1186/s40729-021-00332-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Kern, Karsten Lukmann, Fania Obreja, Karina Al-Maawi, Sara Carla, Bellinghausen Ghanaati, Shahram Rohde, Gernot Sader, Robert Schwarz, Frank Pharyngeal spreading of peri-implant infections under antiresorptive/antiangiogenic therapy |
title | Pharyngeal spreading of peri-implant infections under antiresorptive/antiangiogenic therapy |
title_full | Pharyngeal spreading of peri-implant infections under antiresorptive/antiangiogenic therapy |
title_fullStr | Pharyngeal spreading of peri-implant infections under antiresorptive/antiangiogenic therapy |
title_full_unstemmed | Pharyngeal spreading of peri-implant infections under antiresorptive/antiangiogenic therapy |
title_short | Pharyngeal spreading of peri-implant infections under antiresorptive/antiangiogenic therapy |
title_sort | pharyngeal spreading of peri-implant infections under antiresorptive/antiangiogenic therapy |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172650/ https://www.ncbi.nlm.nih.gov/pubmed/34080056 http://dx.doi.org/10.1186/s40729-021-00332-z |
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