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Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

In mammals, sexual hormones such as estrogens play an essential role in maintaining brain homeostasis and function. Estrogen deficit in the brain induces many undesirable symptoms such as learning and memory impairment, sleep and mood disorders, hot flushes, and fatigue. These symptoms are frequent...

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Autores principales: Echeverria, Valentina, Echeverria, Florencia, Barreto, George E., Echeverría, Javier, Mendoza, Cristhian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172769/
https://www.ncbi.nlm.nih.gov/pubmed/34093183
http://dx.doi.org/10.3389/fphar.2021.644103
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author Echeverria, Valentina
Echeverria, Florencia
Barreto, George E.
Echeverría, Javier
Mendoza, Cristhian
author_facet Echeverria, Valentina
Echeverria, Florencia
Barreto, George E.
Echeverría, Javier
Mendoza, Cristhian
author_sort Echeverria, Valentina
collection PubMed
description In mammals, sexual hormones such as estrogens play an essential role in maintaining brain homeostasis and function. Estrogen deficit in the brain induces many undesirable symptoms such as learning and memory impairment, sleep and mood disorders, hot flushes, and fatigue. These symptoms are frequent in women who reached menopausal age or have had ovariectomy and in men and women subjected to anti-estrogen therapy. Hormone replacement therapy alleviates menopause symptoms; however, it can increase cardiovascular and cancer diseases. In the search for therapeutic alternatives, medicinal plants and specific synthetic and natural molecules with estrogenic effects have attracted widespread attention between the public and the scientific community. Various plants have been used for centuries to alleviate menstrual and menopause symptoms, such as Cranberry, Ginger, Hops, Milk Thistle, Red clover, Salvia officinalis, Soy, Black cohosh, Turnera diffusa, Ushuva, and Vitex. This review aims to highlight current evidence about estrogenic medicinal plants and their pharmacological effects on cognitive deficits induced by estrogen deficiency during menopause and aging.
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spelling pubmed-81727692021-06-04 Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause Echeverria, Valentina Echeverria, Florencia Barreto, George E. Echeverría, Javier Mendoza, Cristhian Front Pharmacol Pharmacology In mammals, sexual hormones such as estrogens play an essential role in maintaining brain homeostasis and function. Estrogen deficit in the brain induces many undesirable symptoms such as learning and memory impairment, sleep and mood disorders, hot flushes, and fatigue. These symptoms are frequent in women who reached menopausal age or have had ovariectomy and in men and women subjected to anti-estrogen therapy. Hormone replacement therapy alleviates menopause symptoms; however, it can increase cardiovascular and cancer diseases. In the search for therapeutic alternatives, medicinal plants and specific synthetic and natural molecules with estrogenic effects have attracted widespread attention between the public and the scientific community. Various plants have been used for centuries to alleviate menstrual and menopause symptoms, such as Cranberry, Ginger, Hops, Milk Thistle, Red clover, Salvia officinalis, Soy, Black cohosh, Turnera diffusa, Ushuva, and Vitex. This review aims to highlight current evidence about estrogenic medicinal plants and their pharmacological effects on cognitive deficits induced by estrogen deficiency during menopause and aging. Frontiers Media S.A. 2021-05-20 /pmc/articles/PMC8172769/ /pubmed/34093183 http://dx.doi.org/10.3389/fphar.2021.644103 Text en Copyright © 2021 Echeverria, Echeverria, Barreto, Echeverría and Mendoza. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Echeverria, Valentina
Echeverria, Florencia
Barreto, George E.
Echeverría, Javier
Mendoza, Cristhian
Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause
title Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause
title_full Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause
title_fullStr Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause
title_full_unstemmed Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause
title_short Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause
title_sort estrogenic plants: to prevent neurodegeneration and memory loss and other symptoms in women after menopause
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172769/
https://www.ncbi.nlm.nih.gov/pubmed/34093183
http://dx.doi.org/10.3389/fphar.2021.644103
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