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Current Advancements in Sactipeptide Natural Products

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing class of natural products that benefited from genome sequencing technology in the past two decades. RiPPs are widely distributed in nature and show diverse chemical structures and rich biological activities. Des...

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Autores principales: Chen, Yunliang, Wang, Jinxiu, Li, Guoquan, Yang, Yunpeng, Ding, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172795/
https://www.ncbi.nlm.nih.gov/pubmed/34095082
http://dx.doi.org/10.3389/fchem.2021.595991
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author Chen, Yunliang
Wang, Jinxiu
Li, Guoquan
Yang, Yunpeng
Ding, Wei
author_facet Chen, Yunliang
Wang, Jinxiu
Li, Guoquan
Yang, Yunpeng
Ding, Wei
author_sort Chen, Yunliang
collection PubMed
description Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing class of natural products that benefited from genome sequencing technology in the past two decades. RiPPs are widely distributed in nature and show diverse chemical structures and rich biological activities. Despite the various structural characteristic of RiPPs, they follow a common biosynthetic logic: a precursor peptide containing an N-terminal leader peptide and a C-terminal core peptide; in some cases,a follower peptide is after the core peptide. The precursor peptide undergoes a series of modification, transport, and cleavage steps to form a mature natural product with specific activities. Sactipeptides (Sulfur-to-alpha carbon thioether cross-linked peptides) belong to RiPPs that show various biological activities such as antibacterial, spermicidal and hemolytic properties. Their common hallmark is an intramolecular thioether bond that crosslinks the sulfur atom of a cysteine residue to the α-carbon of an acceptor amino acid, which is catalyzed by a rSAM enzyme. This review summarizes recent achievements concerning the discovery, distribution, structural elucidation, biosynthesis and application prospects of sactipeptides.
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spelling pubmed-81727952021-06-04 Current Advancements in Sactipeptide Natural Products Chen, Yunliang Wang, Jinxiu Li, Guoquan Yang, Yunpeng Ding, Wei Front Chem Chemistry Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing class of natural products that benefited from genome sequencing technology in the past two decades. RiPPs are widely distributed in nature and show diverse chemical structures and rich biological activities. Despite the various structural characteristic of RiPPs, they follow a common biosynthetic logic: a precursor peptide containing an N-terminal leader peptide and a C-terminal core peptide; in some cases,a follower peptide is after the core peptide. The precursor peptide undergoes a series of modification, transport, and cleavage steps to form a mature natural product with specific activities. Sactipeptides (Sulfur-to-alpha carbon thioether cross-linked peptides) belong to RiPPs that show various biological activities such as antibacterial, spermicidal and hemolytic properties. Their common hallmark is an intramolecular thioether bond that crosslinks the sulfur atom of a cysteine residue to the α-carbon of an acceptor amino acid, which is catalyzed by a rSAM enzyme. This review summarizes recent achievements concerning the discovery, distribution, structural elucidation, biosynthesis and application prospects of sactipeptides. Frontiers Media S.A. 2021-05-20 /pmc/articles/PMC8172795/ /pubmed/34095082 http://dx.doi.org/10.3389/fchem.2021.595991 Text en Copyright © 2021 Chen, Wang, Li, Yang and Ding. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Chen, Yunliang
Wang, Jinxiu
Li, Guoquan
Yang, Yunpeng
Ding, Wei
Current Advancements in Sactipeptide Natural Products
title Current Advancements in Sactipeptide Natural Products
title_full Current Advancements in Sactipeptide Natural Products
title_fullStr Current Advancements in Sactipeptide Natural Products
title_full_unstemmed Current Advancements in Sactipeptide Natural Products
title_short Current Advancements in Sactipeptide Natural Products
title_sort current advancements in sactipeptide natural products
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172795/
https://www.ncbi.nlm.nih.gov/pubmed/34095082
http://dx.doi.org/10.3389/fchem.2021.595991
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