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Clinical Diagnostic Criteria Have a High Impact on the Frequency of Dementia in Late-Stage Parkinson's Disease

Background: Cognitive impairment is a potential late feature of Parkinson's disease (PD). However, studies in patients with late-stage PD are lacking due to the particular characteristics of this population. Objectives: To evaluate the frequency of dementia in late-stage PD patients and to asse...

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Autores principales: Severiano e Sousa, Catarina, Fabbri, Margherita, Godinho, Catarina, Simões, Rita, Chendo, Inês, Coelho, Miguel, Martins, Isabel Pavão, Ferreira, Joaquim J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172803/
https://www.ncbi.nlm.nih.gov/pubmed/34093399
http://dx.doi.org/10.3389/fneur.2021.652424
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author Severiano e Sousa, Catarina
Fabbri, Margherita
Godinho, Catarina
Simões, Rita
Chendo, Inês
Coelho, Miguel
Martins, Isabel Pavão
Ferreira, Joaquim J.
author_facet Severiano e Sousa, Catarina
Fabbri, Margherita
Godinho, Catarina
Simões, Rita
Chendo, Inês
Coelho, Miguel
Martins, Isabel Pavão
Ferreira, Joaquim J.
author_sort Severiano e Sousa, Catarina
collection PubMed
description Background: Cognitive impairment is a potential late feature of Parkinson's disease (PD). However, studies in patients with late-stage PD are lacking due to the particular characteristics of this population. Objectives: To evaluate the frequency of dementia in late-stage PD patients and to assess the impact of using different diagnostic criteria. Methods: We conducted a cross-sectional study to estimate the frequency of dementia in late-stage PD patients using the International Parkinson and Movement Disorders Society (MDS) (Level II) clinical diagnostic criteria as the primary outcome. We also applied other diagnostic criteria [MDS (Level I), DSM-IV, and DSM-5 criteria] to determine their applicability and impact on dementia frequency. Results: 93 participants with a mean age of 75.8 years (SD 6.8) and 16.5 years (SD 7.5) of disease duration were included. 64.3% were classified as demented using the International Parkinson and Movement Disorders Society (MDS) (Level II) clinical diagnostic criteria. We observed a high discrepancy on the frequency of dementia depending on the criteria applied [6.2% with MDS (Level I), 58.8% with DSM-IV, and 72.0% with DSM-5 criteria]. Conclusions: We found a frequency of dementia below what was observed in similar populations. The particular characteristics of our sample may have contributed as protective factors for late-stage dementia. Dementia frequency varied depending on the criteria used mainly due to the presence of major depression.
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spelling pubmed-81728032021-06-04 Clinical Diagnostic Criteria Have a High Impact on the Frequency of Dementia in Late-Stage Parkinson's Disease Severiano e Sousa, Catarina Fabbri, Margherita Godinho, Catarina Simões, Rita Chendo, Inês Coelho, Miguel Martins, Isabel Pavão Ferreira, Joaquim J. Front Neurol Neurology Background: Cognitive impairment is a potential late feature of Parkinson's disease (PD). However, studies in patients with late-stage PD are lacking due to the particular characteristics of this population. Objectives: To evaluate the frequency of dementia in late-stage PD patients and to assess the impact of using different diagnostic criteria. Methods: We conducted a cross-sectional study to estimate the frequency of dementia in late-stage PD patients using the International Parkinson and Movement Disorders Society (MDS) (Level II) clinical diagnostic criteria as the primary outcome. We also applied other diagnostic criteria [MDS (Level I), DSM-IV, and DSM-5 criteria] to determine their applicability and impact on dementia frequency. Results: 93 participants with a mean age of 75.8 years (SD 6.8) and 16.5 years (SD 7.5) of disease duration were included. 64.3% were classified as demented using the International Parkinson and Movement Disorders Society (MDS) (Level II) clinical diagnostic criteria. We observed a high discrepancy on the frequency of dementia depending on the criteria applied [6.2% with MDS (Level I), 58.8% with DSM-IV, and 72.0% with DSM-5 criteria]. Conclusions: We found a frequency of dementia below what was observed in similar populations. The particular characteristics of our sample may have contributed as protective factors for late-stage dementia. Dementia frequency varied depending on the criteria used mainly due to the presence of major depression. Frontiers Media S.A. 2021-05-20 /pmc/articles/PMC8172803/ /pubmed/34093399 http://dx.doi.org/10.3389/fneur.2021.652424 Text en Copyright © 2021 Severiano e Sousa, Fabbri, Godinho, Simões, Chendo, Coelho, Martins and Ferreira. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Severiano e Sousa, Catarina
Fabbri, Margherita
Godinho, Catarina
Simões, Rita
Chendo, Inês
Coelho, Miguel
Martins, Isabel Pavão
Ferreira, Joaquim J.
Clinical Diagnostic Criteria Have a High Impact on the Frequency of Dementia in Late-Stage Parkinson's Disease
title Clinical Diagnostic Criteria Have a High Impact on the Frequency of Dementia in Late-Stage Parkinson's Disease
title_full Clinical Diagnostic Criteria Have a High Impact on the Frequency of Dementia in Late-Stage Parkinson's Disease
title_fullStr Clinical Diagnostic Criteria Have a High Impact on the Frequency of Dementia in Late-Stage Parkinson's Disease
title_full_unstemmed Clinical Diagnostic Criteria Have a High Impact on the Frequency of Dementia in Late-Stage Parkinson's Disease
title_short Clinical Diagnostic Criteria Have a High Impact on the Frequency of Dementia in Late-Stage Parkinson's Disease
title_sort clinical diagnostic criteria have a high impact on the frequency of dementia in late-stage parkinson's disease
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172803/
https://www.ncbi.nlm.nih.gov/pubmed/34093399
http://dx.doi.org/10.3389/fneur.2021.652424
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