MRISCs protect colonic stem cells from inflammatory damage

Increasing evidence suggest functional roles of subepithelial mesenchymal niche cells in maintaining intestinal stem cells and in modulating the pathogenesis of various intestinal diseases in mammals. A recent study reported the discovery of a new population of stromal cells in mice termed MAP3K2-Re...

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Autores principales: Zhu, Guoli, Xi, Rongwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172814/
https://www.ncbi.nlm.nih.gov/pubmed/34080092
http://dx.doi.org/10.1186/s13619-021-00086-4
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author Zhu, Guoli
Xi, Rongwen
author_facet Zhu, Guoli
Xi, Rongwen
author_sort Zhu, Guoli
collection PubMed
description Increasing evidence suggest functional roles of subepithelial mesenchymal niche cells in maintaining intestinal stem cells and in modulating the pathogenesis of various intestinal diseases in mammals. A recent study reported the discovery of a new population of stromal cells in mice termed MAP3K2-Regulated Intestinal Stromal Cells (MRISCs); these cells reside at the base of colonic crypt and function to protect colonic stem cells during colonic inflammation by expressing the Wnt agonist R-spondin1 (Rspo1).
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spelling pubmed-81728142021-06-17 MRISCs protect colonic stem cells from inflammatory damage Zhu, Guoli Xi, Rongwen Cell Regen Research Highlight Increasing evidence suggest functional roles of subepithelial mesenchymal niche cells in maintaining intestinal stem cells and in modulating the pathogenesis of various intestinal diseases in mammals. A recent study reported the discovery of a new population of stromal cells in mice termed MAP3K2-Regulated Intestinal Stromal Cells (MRISCs); these cells reside at the base of colonic crypt and function to protect colonic stem cells during colonic inflammation by expressing the Wnt agonist R-spondin1 (Rspo1). Springer Singapore 2021-06-03 /pmc/articles/PMC8172814/ /pubmed/34080092 http://dx.doi.org/10.1186/s13619-021-00086-4 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Highlight
Zhu, Guoli
Xi, Rongwen
MRISCs protect colonic stem cells from inflammatory damage
title MRISCs protect colonic stem cells from inflammatory damage
title_full MRISCs protect colonic stem cells from inflammatory damage
title_fullStr MRISCs protect colonic stem cells from inflammatory damage
title_full_unstemmed MRISCs protect colonic stem cells from inflammatory damage
title_short MRISCs protect colonic stem cells from inflammatory damage
title_sort mriscs protect colonic stem cells from inflammatory damage
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172814/
https://www.ncbi.nlm.nih.gov/pubmed/34080092
http://dx.doi.org/10.1186/s13619-021-00086-4
work_keys_str_mv AT zhuguoli mriscsprotectcolonicstemcellsfrominflammatorydamage
AT xirongwen mriscsprotectcolonicstemcellsfrominflammatorydamage

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