Cargando…
Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations
Uveal melanoma is a malignant neoplasm that derives from pigmented melanocytes of the uvea and involves, in order of decreasing prevalence, the choroid, ciliary body and iris. Its prognosis is related to histopathologic and genetic features, tumor size and location, extraocular extension. The diagno...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172816/ https://www.ncbi.nlm.nih.gov/pubmed/34080069 http://dx.doi.org/10.1186/s13244-021-01000-x |
_version_ | 1783702590400233472 |
---|---|
author | Foti, Pietro Valerio Travali, Mario Farina, Renato Palmucci, Stefano Spatola, Corrado Raffaele, Luigi Salamone, Vincenzo Caltabiano, Rosario Broggi, Giuseppe Puzzo, Lidia Russo, Andrea Reibaldi, Michele Longo, Antonio Vigneri, Paolo Avitabile, Teresio Ettorre, Giovani Carlo Basile, Antonio |
author_facet | Foti, Pietro Valerio Travali, Mario Farina, Renato Palmucci, Stefano Spatola, Corrado Raffaele, Luigi Salamone, Vincenzo Caltabiano, Rosario Broggi, Giuseppe Puzzo, Lidia Russo, Andrea Reibaldi, Michele Longo, Antonio Vigneri, Paolo Avitabile, Teresio Ettorre, Giovani Carlo Basile, Antonio |
author_sort | Foti, Pietro Valerio |
collection | PubMed |
description | Uveal melanoma is a malignant neoplasm that derives from pigmented melanocytes of the uvea and involves, in order of decreasing prevalence, the choroid, ciliary body and iris. Its prognosis is related to histopathologic and genetic features, tumor size and location, extraocular extension. The diagnosis is fundamentally based on clinical evaluation (ophthalmoscopy, biomicroscopy) and ultrasonography. MRI is useful in case of untransparent lens or subretinal effusion. Moreover, MRI has a significant role to confirm the diagnosis, in the evaluation of the local extent of the disease with implications for treatment planning, and in the follow-up after radiotherapy treatment. Uveal melanoma can show different morphologic features (lentiform, dome or mushroom shape) and often determines retinal detachment. MR appearance of uveal melanoma mainly depends on the melanin content. Uveal melanoma typically displays high signal intensity on T1-weighted images and low signal intensity on T2-weighted images. Nevertheless, imaging appearance may be variable based on the degree of pigmentation and the presence of areas of necrosis or cavitation. Differential diagnosis includes other uveal lesions. The radiologists and in particular MRI play a significant role in the clinical management of uveal melanoma. The purpose of this pictorial review is to provide the radiologists with awareness about diagnostic methods and therapeutic options of uveal melanoma. In the present first section we summarize the MR anatomy of the eye and describe ophthalmological and radiological imaging techniques to diagnose uveal melanomas, with emphasis on the role of MR imaging. Additionally, we review MR imaging appearance of uveal melanomas. |
format | Online Article Text |
id | pubmed-8172816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-81728162021-06-17 Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations Foti, Pietro Valerio Travali, Mario Farina, Renato Palmucci, Stefano Spatola, Corrado Raffaele, Luigi Salamone, Vincenzo Caltabiano, Rosario Broggi, Giuseppe Puzzo, Lidia Russo, Andrea Reibaldi, Michele Longo, Antonio Vigneri, Paolo Avitabile, Teresio Ettorre, Giovani Carlo Basile, Antonio Insights Imaging Educational Review Uveal melanoma is a malignant neoplasm that derives from pigmented melanocytes of the uvea and involves, in order of decreasing prevalence, the choroid, ciliary body and iris. Its prognosis is related to histopathologic and genetic features, tumor size and location, extraocular extension. The diagnosis is fundamentally based on clinical evaluation (ophthalmoscopy, biomicroscopy) and ultrasonography. MRI is useful in case of untransparent lens or subretinal effusion. Moreover, MRI has a significant role to confirm the diagnosis, in the evaluation of the local extent of the disease with implications for treatment planning, and in the follow-up after radiotherapy treatment. Uveal melanoma can show different morphologic features (lentiform, dome or mushroom shape) and often determines retinal detachment. MR appearance of uveal melanoma mainly depends on the melanin content. Uveal melanoma typically displays high signal intensity on T1-weighted images and low signal intensity on T2-weighted images. Nevertheless, imaging appearance may be variable based on the degree of pigmentation and the presence of areas of necrosis or cavitation. Differential diagnosis includes other uveal lesions. The radiologists and in particular MRI play a significant role in the clinical management of uveal melanoma. The purpose of this pictorial review is to provide the radiologists with awareness about diagnostic methods and therapeutic options of uveal melanoma. In the present first section we summarize the MR anatomy of the eye and describe ophthalmological and radiological imaging techniques to diagnose uveal melanomas, with emphasis on the role of MR imaging. Additionally, we review MR imaging appearance of uveal melanomas. Springer International Publishing 2021-06-03 /pmc/articles/PMC8172816/ /pubmed/34080069 http://dx.doi.org/10.1186/s13244-021-01000-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Educational Review Foti, Pietro Valerio Travali, Mario Farina, Renato Palmucci, Stefano Spatola, Corrado Raffaele, Luigi Salamone, Vincenzo Caltabiano, Rosario Broggi, Giuseppe Puzzo, Lidia Russo, Andrea Reibaldi, Michele Longo, Antonio Vigneri, Paolo Avitabile, Teresio Ettorre, Giovani Carlo Basile, Antonio Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations |
title | Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations |
title_full | Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations |
title_fullStr | Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations |
title_full_unstemmed | Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations |
title_short | Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations |
title_sort | diagnostic methods and therapeutic options of uveal melanoma with emphasis on mr imaging—part i: mr imaging with pathologic correlation and technical considerations |
topic | Educational Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172816/ https://www.ncbi.nlm.nih.gov/pubmed/34080069 http://dx.doi.org/10.1186/s13244-021-01000-x |
work_keys_str_mv | AT fotipietrovalerio diagnosticmethodsandtherapeuticoptionsofuvealmelanomawithemphasisonmrimagingpartimrimagingwithpathologiccorrelationandtechnicalconsiderations AT travalimario diagnosticmethodsandtherapeuticoptionsofuvealmelanomawithemphasisonmrimagingpartimrimagingwithpathologiccorrelationandtechnicalconsiderations AT farinarenato diagnosticmethodsandtherapeuticoptionsofuvealmelanomawithemphasisonmrimagingpartimrimagingwithpathologiccorrelationandtechnicalconsiderations AT palmuccistefano diagnosticmethodsandtherapeuticoptionsofuvealmelanomawithemphasisonmrimagingpartimrimagingwithpathologiccorrelationandtechnicalconsiderations AT spatolacorrado diagnosticmethodsandtherapeuticoptionsofuvealmelanomawithemphasisonmrimagingpartimrimagingwithpathologiccorrelationandtechnicalconsiderations AT raffaeleluigi diagnosticmethodsandtherapeuticoptionsofuvealmelanomawithemphasisonmrimagingpartimrimagingwithpathologiccorrelationandtechnicalconsiderations AT salamonevincenzo diagnosticmethodsandtherapeuticoptionsofuvealmelanomawithemphasisonmrimagingpartimrimagingwithpathologiccorrelationandtechnicalconsiderations AT caltabianorosario diagnosticmethodsandtherapeuticoptionsofuvealmelanomawithemphasisonmrimagingpartimrimagingwithpathologiccorrelationandtechnicalconsiderations AT broggigiuseppe diagnosticmethodsandtherapeuticoptionsofuvealmelanomawithemphasisonmrimagingpartimrimagingwithpathologiccorrelationandtechnicalconsiderations AT puzzolidia diagnosticmethodsandtherapeuticoptionsofuvealmelanomawithemphasisonmrimagingpartimrimagingwithpathologiccorrelationandtechnicalconsiderations AT russoandrea diagnosticmethodsandtherapeuticoptionsofuvealmelanomawithemphasisonmrimagingpartimrimagingwithpathologiccorrelationandtechnicalconsiderations AT reibaldimichele diagnosticmethodsandtherapeuticoptionsofuvealmelanomawithemphasisonmrimagingpartimrimagingwithpathologiccorrelationandtechnicalconsiderations AT longoantonio diagnosticmethodsandtherapeuticoptionsofuvealmelanomawithemphasisonmrimagingpartimrimagingwithpathologiccorrelationandtechnicalconsiderations AT vigneripaolo diagnosticmethodsandtherapeuticoptionsofuvealmelanomawithemphasisonmrimagingpartimrimagingwithpathologiccorrelationandtechnicalconsiderations AT avitabileteresio diagnosticmethodsandtherapeuticoptionsofuvealmelanomawithemphasisonmrimagingpartimrimagingwithpathologiccorrelationandtechnicalconsiderations AT ettorregiovanicarlo diagnosticmethodsandtherapeuticoptionsofuvealmelanomawithemphasisonmrimagingpartimrimagingwithpathologiccorrelationandtechnicalconsiderations AT basileantonio diagnosticmethodsandtherapeuticoptionsofuvealmelanomawithemphasisonmrimagingpartimrimagingwithpathologiccorrelationandtechnicalconsiderations |