Cargando…

Structural and phylogenetic analyses of resistance to next-generation aminoglycosides conferred by AAC(2′) enzymes

Plazomicin is currently the only next-generation aminoglycoside approved for clinical use that has the potential of evading the effects of widespread enzymatic resistance factors. However, plazomicin is still susceptible to the action of the resistance enzyme AAC(2′)-Ia from Providencia stuartii. As...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bassenden, Angelia V., Dumalo, Linda, Park, Jaeok, Blanchet, Jonathan, Maiti, Krishnagopal, Arya, Dev P., Berghuis, Albert M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172861/ https://www.ncbi.nlm.nih.gov/pubmed/34078922 http://dx.doi.org/10.1038/s41598-021-89446-3

Ejemplares similares

Structural basis for plazomicin antibiotic action and resistance
por: Golkar, Tolou, et al.
Publicado: (2021)

Structural elucidation of substrate-bound aminoglycoside acetyltransferase (3)-IIIa
por: Zieliński, Michał, et al.
Publicado: (2022)

Aminoglycoside resistance profile and structural architecture of the aminoglycoside acetyltransferase AAC(6')-Im
por: Smith, Clyde A., et al.
Publicado: (2017)

Rise and dissemination of aminoglycoside resistance: the aac(6′)-Ib paradigm
por: Ramirez, María S., et al.
Publicado: (2013)

The prevalence of aminoglycoside-modifying enzyme genes (aac (6′)-I, aac (6′)-II, ant (2″)-I, aph (3′)-VI) in Pseudomonas aeruginosa
por: Vaziri, Farzam, et al.
Publicado: (2011)

Human isoprenoid synthase enzymes as therapeutic targets
por: Park, Jaeok, et al.
Publicado: (2014)

Epidemiologic, Phenotypic, and Structural Characterization of Aminoglycoside-Resistance Gene aac(3)-IV
por: Plattner, Michel, et al.
Publicado: (2020)

Aminoglycoside Susceptibility Profiles of Enterobacter cloacae Isolates Harboring the aac(6')-Ib Gene
por: Kim, Soo-Young, et al.
Publicado: (2011)

Aminoglycoside 6′-N-acetyltransferase Type Ib [AAC(6′)-Ib]-Mediated Aminoglycoside Resistance: Phenotypic Conversion to Susceptibility by Silver Ions
por: Reeves, Craig M., et al.
Publicado: (2020)

A pH Sensitive High-Throughput Assay for miRNA Binding of a Peptide-Aminoglycoside (PA) Library
por: Watkins, Derrick, et al.
Publicado: (2015)

Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance
por: Shi, Kun, et al.
Publicado: (2013)

Resistome analysis of Mycobacterium tuberculosis: Identification of aminoglycoside 2'-Nacetyltransferase (AAC) as co-target for drug desigining
por: Joshi, Rakesh S, et al.
Publicado: (2013)

Susceptibility to Aminoglycosides and Distribution of aph and aac(3)-XI Genes among Corynebacterium striatum Clinical Isolates
por: Navas, Jesús, et al.
Publicado: (2016)

Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s active site closure
por: Park, Jaeok, et al.
Publicado: (2012)

Crystal Structures of Two Aminoglycoside Kinases Bound with a Eukaryotic Protein Kinase Inhibitor
por: Fong, Desiree H., et al.
Publicado: (2011)

Structural and functional insights into esterase-mediated macrolide resistance
por: Zieliński, Michał, et al.
Publicado: (2021)

Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate
por: Park, Jaeok, et al.
Publicado: (2014)

Revisiting Polymorphic Diversity of Aminoglycoside N-Acetyltransferase AAC(6′)-Ib Based on Bacterial Genomes of Human, Animal, and Environmental Origins
por: Kim, Dae-Wi, et al.
Publicado: (2018)

Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
por: Park, Jaeok, et al.
Publicado: (2017)

Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective
por: Park, Jaeok, et al.
Publicado: (2021)

Identification and characterization of a novel 6′-N-aminoglycoside acetyltransferase AAC(6′)-Va from a clinical isolate of Aeromonas hydrophila
por: Zhang, Guozhi, et al.
Publicado: (2023)

Stenotrophomonas maltophilia from Nepal Producing Two Novel Antibiotic Inactivating Enzymes, a Class A β-Lactamase KBL-1 and an Aminoglycoside 6′-N-Acetyltransferase AAC(6′)-Iap
por: Kawauchi, Ryota, et al.
Publicado: (2022)

AAC studies
por: Kewell, J
Publicado: (1989)

AAC Studies
por: Kewell, J
Publicado: (1989)

AAC modes
por: Eriksson, T
Publicado: (1992)

Increasing Prevalence of Aminoglycoside-Resistant Enterococcus faecalis Isolates Due to the aac(6’)-aph(2”) Gene: A Therapeutic Problem in Kermanshah, Iran
por: Khani, Mitra, et al.
Publicado: (2016)

Inhibition of Aminoglycoside 6′-N-acetyltransferase Type Ib (AAC(6′)-Ib): Structure–Activity Relationship of Substituted Pyrrolidine Pentamine Derivatives as Inhibitors
por: Rocha, Kenneth, et al.
Publicado: (2021)

Analysis of Aminoglycoside Modifying Enzyme Genes Responsible for High-Level Aminoglycoside Resistance among Enterococcal Isolates
por: Shete, Vishal, et al.
Publicado: (2017)

Role of Aminoglycoside-Modifying Enzymes (AMEs) in Resistance to Aminoglycosides among Clinical Isolates of Pseudomonas aeruginosa in the North of Iran
por: Ahmadian, Leila, et al.
Publicado: (2021)

Emergence of the Novel Aminoglycoside Acetyltransferase Variant aac(6′)-Ib-D179Y and Acquisition of Colistin Heteroresistance in Carbapenem-Resistant Klebsiella pneumoniae Due to a Disrupting Mutation in the DNA Repair Enzyme MutS
por: Sato, Toyotaka, et al.
Publicado: (2020)

The prevalence of aminoglycoside-modifying enzyme and virulence genes among enterococci with high-level aminoglycoside resistance in Inner Mongolia, China
por: Niu, Haiying, et al.
Publicado: (2016)

Prevalence of Aminoglycoside Resistance and Aminoglycoside Modifying Enzymes in Acinetobacter baumannii Among Intensive Care Unit Patients, Ismailia, Egypt
por: Kishk, Rania, et al.
Publicado: (2021)

AAC L. Perry
Publicado: (2016)

Initial performance of AAC
por: Jones, Eifionydd
Publicado: (1987)

Initial performance of AAC
por: Jones, E
Publicado: (1988)

AAC RF systems
por: Soby, L
Publicado: (1992)

Signaux Analogiques AAC
por: Ottaviani, J, et al.
Publicado: (1990)

Signaux analogiques AAC
por: Ottaviani, J, et al.
Publicado: (1990)

Tele-AAC Resolution
por: Anderson, Kate, et al.
Publicado: (2012)

Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase
por: Park, Jaeok, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_44140l06uhl5o4be955qkeh2qd