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Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis
The female mammary epithelium undergoes reorganization during development, pregnancy, and menopause, linking higher risk with breast cancer development. To characterize these periods of complex remodeling, here we report integrated 50 K mouse and 24 K human mammary epithelial cell atlases obtained b...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172904/ https://www.ncbi.nlm.nih.gov/pubmed/34079055 http://dx.doi.org/10.1038/s42003-021-02201-2 |
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author | Saeki, Kohei Chang, Gregory Kanaya, Noriko Wu, Xiwei Wang, Jinhui Bernal, Lauren Ha, Desiree Neuhausen, Susan L. Chen, Shiuan |
author_facet | Saeki, Kohei Chang, Gregory Kanaya, Noriko Wu, Xiwei Wang, Jinhui Bernal, Lauren Ha, Desiree Neuhausen, Susan L. Chen, Shiuan |
author_sort | Saeki, Kohei |
collection | PubMed |
description | The female mammary epithelium undergoes reorganization during development, pregnancy, and menopause, linking higher risk with breast cancer development. To characterize these periods of complex remodeling, here we report integrated 50 K mouse and 24 K human mammary epithelial cell atlases obtained by single-cell RNA sequencing, which covers most lifetime stages. Our results indicate a putative trajectory that originates from embryonic mammary stem cells which differentiates into three epithelial lineages (basal, luminal hormone-sensing, and luminal alveolar), presumably arising from unipotent progenitors in postnatal glands. The lineage-specific genes infer cells of origin of breast cancer using The Cancer Genome Atlas data and single-cell RNA sequencing of human breast cancer, as well as the association of gland reorganization to different breast cancer subtypes. This comprehensive mammary cell gene expression atlas (https://mouse-mammary-epithelium-integrated.cells.ucsc.edu) presents insights into the impact of the internal and external stimuli on the mammary epithelium at an advanced resolution. |
format | Online Article Text |
id | pubmed-8172904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-81729042021-06-07 Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis Saeki, Kohei Chang, Gregory Kanaya, Noriko Wu, Xiwei Wang, Jinhui Bernal, Lauren Ha, Desiree Neuhausen, Susan L. Chen, Shiuan Commun Biol Article The female mammary epithelium undergoes reorganization during development, pregnancy, and menopause, linking higher risk with breast cancer development. To characterize these periods of complex remodeling, here we report integrated 50 K mouse and 24 K human mammary epithelial cell atlases obtained by single-cell RNA sequencing, which covers most lifetime stages. Our results indicate a putative trajectory that originates from embryonic mammary stem cells which differentiates into three epithelial lineages (basal, luminal hormone-sensing, and luminal alveolar), presumably arising from unipotent progenitors in postnatal glands. The lineage-specific genes infer cells of origin of breast cancer using The Cancer Genome Atlas data and single-cell RNA sequencing of human breast cancer, as well as the association of gland reorganization to different breast cancer subtypes. This comprehensive mammary cell gene expression atlas (https://mouse-mammary-epithelium-integrated.cells.ucsc.edu) presents insights into the impact of the internal and external stimuli on the mammary epithelium at an advanced resolution. Nature Publishing Group UK 2021-06-02 /pmc/articles/PMC8172904/ /pubmed/34079055 http://dx.doi.org/10.1038/s42003-021-02201-2 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Saeki, Kohei Chang, Gregory Kanaya, Noriko Wu, Xiwei Wang, Jinhui Bernal, Lauren Ha, Desiree Neuhausen, Susan L. Chen, Shiuan Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis |
title | Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis |
title_full | Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis |
title_fullStr | Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis |
title_full_unstemmed | Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis |
title_short | Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis |
title_sort | mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172904/ https://www.ncbi.nlm.nih.gov/pubmed/34079055 http://dx.doi.org/10.1038/s42003-021-02201-2 |
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