Gata2-L359V impairs primitive and definitive hematopoiesis and blocks cell differentiation in murine chronic myelogenous leukemia model

GATA2, a key transcription factor in hematopoiesis, is frequently mutated in hematopoietic malignancies. How the GATA2 mutants contribute to hematopoiesis and malignant transformation remains largely unexplored. Here, we report that Gata2-L359V mutation impeded hematopoietic differentiation in murin...

Descripción completa

Detalles Bibliográficos
Autores principales: Fu, Ya-Kai, Tan, Yun, Wu, Bo, Dai, Yu-Ting, Xu, Xiao-Guang, Pan, Meng-Meng, Chen, Zhi-Wei, Qiao, Niu, Wu, Jing, Jiang, Lu, Lu, Jing, Chen, Bing, Rein, Avigail, Izraeli, Shai, Sun, Xiao-Jian, Huang, Jin-Yan, Huang, Qiu-Hua, Chen, Zhu, Chen, Sai-Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173010/
https://www.ncbi.nlm.nih.gov/pubmed/34078881
http://dx.doi.org/10.1038/s41419-021-03826-1

Ejemplares similares

Ejemplares similares