Cargando…

Childhood Clear Cell Sarcoma of Kidney: Incidence and Survival

This study is to describe current incidence of childhood clear cell sarcoma of kidney (CCSK) and to investigate the present survival of this cancer. Surveillance, Epidemiology, and End Result (SEER) data was used to identify children with CCSK and Wilms tumor (WT) aged 0–19 years in the US. Age-adju...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Hui, Cheng, Qi-Yuan, Zhao, Qian, Tao, Long-Xiang, Zhang, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173214/
https://www.ncbi.nlm.nih.gov/pubmed/34095035
http://dx.doi.org/10.3389/fped.2021.675373
_version_ 1783702681043337216
author Gao, Hui
Cheng, Qi-Yuan
Zhao, Qian
Tao, Long-Xiang
Zhang, Cheng
author_facet Gao, Hui
Cheng, Qi-Yuan
Zhao, Qian
Tao, Long-Xiang
Zhang, Cheng
author_sort Gao, Hui
collection PubMed
description This study is to describe current incidence of childhood clear cell sarcoma of kidney (CCSK) and to investigate the present survival of this cancer. Surveillance, Epidemiology, and End Result (SEER) data was used to identify children with CCSK and Wilms tumor (WT) aged 0–19 years in the US. Age-adjusted incidences were estimated over the decades. Age- and sex-specific epidemiology was also presented. Propensity score matching was used to balance features of CCSK and WT cases. Log rank test was used to compare survivals and Cox regression was used to evaluate independent effects of factors. The present age-adjusted incidence of childhood CCSK was 0.205 per million, which remained stable for years and ranked third in all pediatric renal tumors. The incidence rate ratios for boy and age under 4 were 3 and 21, respectively. The current 5-year overall survival (OS) rate for CCSK was 87%, which is not evidently inferior to that for WT (90%); however the outcome of CCSK was significantly poorer if both groups were well-balanced (OS rate was 86 vs. 95%). Early year of diagnosis and distant metastasis were independent survival factors. In conclusion, occurrence of CCSK remains stable over the years, with an age-adjusted incidence of 0.205 per million. Boy and age under 4 are risk factors for tumor development. CCSK currently has a favorable outcome but its nature may be more aggressive than common kidney tumor, which in turn proves efficacy of modern treatment.
format Online
Article
Text
id pubmed-8173214
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-81732142021-06-04 Childhood Clear Cell Sarcoma of Kidney: Incidence and Survival Gao, Hui Cheng, Qi-Yuan Zhao, Qian Tao, Long-Xiang Zhang, Cheng Front Pediatr Pediatrics This study is to describe current incidence of childhood clear cell sarcoma of kidney (CCSK) and to investigate the present survival of this cancer. Surveillance, Epidemiology, and End Result (SEER) data was used to identify children with CCSK and Wilms tumor (WT) aged 0–19 years in the US. Age-adjusted incidences were estimated over the decades. Age- and sex-specific epidemiology was also presented. Propensity score matching was used to balance features of CCSK and WT cases. Log rank test was used to compare survivals and Cox regression was used to evaluate independent effects of factors. The present age-adjusted incidence of childhood CCSK was 0.205 per million, which remained stable for years and ranked third in all pediatric renal tumors. The incidence rate ratios for boy and age under 4 were 3 and 21, respectively. The current 5-year overall survival (OS) rate for CCSK was 87%, which is not evidently inferior to that for WT (90%); however the outcome of CCSK was significantly poorer if both groups were well-balanced (OS rate was 86 vs. 95%). Early year of diagnosis and distant metastasis were independent survival factors. In conclusion, occurrence of CCSK remains stable over the years, with an age-adjusted incidence of 0.205 per million. Boy and age under 4 are risk factors for tumor development. CCSK currently has a favorable outcome but its nature may be more aggressive than common kidney tumor, which in turn proves efficacy of modern treatment. Frontiers Media S.A. 2021-05-20 /pmc/articles/PMC8173214/ /pubmed/34095035 http://dx.doi.org/10.3389/fped.2021.675373 Text en Copyright © 2021 Gao, Cheng, Zhao, Tao and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Gao, Hui
Cheng, Qi-Yuan
Zhao, Qian
Tao, Long-Xiang
Zhang, Cheng
Childhood Clear Cell Sarcoma of Kidney: Incidence and Survival
title Childhood Clear Cell Sarcoma of Kidney: Incidence and Survival
title_full Childhood Clear Cell Sarcoma of Kidney: Incidence and Survival
title_fullStr Childhood Clear Cell Sarcoma of Kidney: Incidence and Survival
title_full_unstemmed Childhood Clear Cell Sarcoma of Kidney: Incidence and Survival
title_short Childhood Clear Cell Sarcoma of Kidney: Incidence and Survival
title_sort childhood clear cell sarcoma of kidney: incidence and survival
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173214/
https://www.ncbi.nlm.nih.gov/pubmed/34095035
http://dx.doi.org/10.3389/fped.2021.675373
work_keys_str_mv AT gaohui childhoodclearcellsarcomaofkidneyincidenceandsurvival
AT chengqiyuan childhoodclearcellsarcomaofkidneyincidenceandsurvival
AT zhaoqian childhoodclearcellsarcomaofkidneyincidenceandsurvival
AT taolongxiang childhoodclearcellsarcomaofkidneyincidenceandsurvival
AT zhangcheng childhoodclearcellsarcomaofkidneyincidenceandsurvival