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Relative Children’s Lipid Accumulation Product Is a Novel Indicator for Metabolic Syndrome

BACKGROUND: The children’s lipid accumulation product (CLAP) is associated with MS in Chinese children and adolescents. The aim of this study was to develop a more effective indicator, the relative children's lipid accumulation product (RCLAP) was evaluated for correlation with MS and the densi...

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Autores principales: Zhang, Li, Zhang, Zizhe, Wang, Bangxuan, Yuan, Yongting, Sun, Lili, Gao, Huaiquan, Fu, Lianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173219/
https://www.ncbi.nlm.nih.gov/pubmed/34093432
http://dx.doi.org/10.3389/fendo.2021.645825
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author Zhang, Li
Zhang, Zizhe
Wang, Bangxuan
Yuan, Yongting
Sun, Lili
Gao, Huaiquan
Fu, Lianguo
author_facet Zhang, Li
Zhang, Zizhe
Wang, Bangxuan
Yuan, Yongting
Sun, Lili
Gao, Huaiquan
Fu, Lianguo
author_sort Zhang, Li
collection PubMed
description BACKGROUND: The children’s lipid accumulation product (CLAP) is associated with MS in Chinese children and adolescents. The aim of this study was to develop a more effective indicator, the relative children's lipid accumulation product (RCLAP) was evaluated for correlation with MS and the density of lipid accumulation. METHODS: A stratified cluster sampling method was used to recruit 683 students aged 8–15 years in this study. The presence of MS was defined according to the NCEP-ATP III criteria. The participants’ guardians signed informed consent before the medical examination. This study was approved by the Medical Ethics Committee of the Bengbu Medical College [(2015) No.003] and was conducted in accordance with the Declaration of Helsinki. RESULTS: The overall prevalence of MS was 4.8% (male 6.6%, female 2.8%). After adjusting for sedentary activity time, relative children's lipid accumulation product per height (RCLAP-H) and relative children's lipid accumulation product per sitting height (RCLAP-SH) significantly increased the risk of MS in girls [OR (95% CI): 96.13 (11.11–831.97) and 96.13 (11.11–831.97), respectively]. After adjusting for ages and moderate-to-vigorous physical activity time, RCLAP-H, and RCLAP-SH significantly increased the risk of MS in boys [OR (95% CI): 171.75 (33.60–878.00) and 133.18 (27.65–641.39), respectively]. The AUCs of RCLAP-H and RCLAP-SH for predicting MS were 0.950, 0.948 in girls, and 0.952, 0.952 in boys, which were higher than BMI, WHtR, Tg/HDL-C, CLAP, and CLAP combining height, sitting height. CONCLUSIONS: The RCLAP-H and RCLAP-SH were more effective indicators for predicting MS than BMI, WHtR, Tg/HDL-C, and CLAP in children and adolescents.
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spelling pubmed-81732192021-06-04 Relative Children’s Lipid Accumulation Product Is a Novel Indicator for Metabolic Syndrome Zhang, Li Zhang, Zizhe Wang, Bangxuan Yuan, Yongting Sun, Lili Gao, Huaiquan Fu, Lianguo Front Endocrinol (Lausanne) Endocrinology BACKGROUND: The children’s lipid accumulation product (CLAP) is associated with MS in Chinese children and adolescents. The aim of this study was to develop a more effective indicator, the relative children's lipid accumulation product (RCLAP) was evaluated for correlation with MS and the density of lipid accumulation. METHODS: A stratified cluster sampling method was used to recruit 683 students aged 8–15 years in this study. The presence of MS was defined according to the NCEP-ATP III criteria. The participants’ guardians signed informed consent before the medical examination. This study was approved by the Medical Ethics Committee of the Bengbu Medical College [(2015) No.003] and was conducted in accordance with the Declaration of Helsinki. RESULTS: The overall prevalence of MS was 4.8% (male 6.6%, female 2.8%). After adjusting for sedentary activity time, relative children's lipid accumulation product per height (RCLAP-H) and relative children's lipid accumulation product per sitting height (RCLAP-SH) significantly increased the risk of MS in girls [OR (95% CI): 96.13 (11.11–831.97) and 96.13 (11.11–831.97), respectively]. After adjusting for ages and moderate-to-vigorous physical activity time, RCLAP-H, and RCLAP-SH significantly increased the risk of MS in boys [OR (95% CI): 171.75 (33.60–878.00) and 133.18 (27.65–641.39), respectively]. The AUCs of RCLAP-H and RCLAP-SH for predicting MS were 0.950, 0.948 in girls, and 0.952, 0.952 in boys, which were higher than BMI, WHtR, Tg/HDL-C, CLAP, and CLAP combining height, sitting height. CONCLUSIONS: The RCLAP-H and RCLAP-SH were more effective indicators for predicting MS than BMI, WHtR, Tg/HDL-C, and CLAP in children and adolescents. Frontiers Media S.A. 2021-05-20 /pmc/articles/PMC8173219/ /pubmed/34093432 http://dx.doi.org/10.3389/fendo.2021.645825 Text en Copyright © 2021 Zhang, Zhang, Wang, Yuan, Sun, Gao and Fu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zhang, Li
Zhang, Zizhe
Wang, Bangxuan
Yuan, Yongting
Sun, Lili
Gao, Huaiquan
Fu, Lianguo
Relative Children’s Lipid Accumulation Product Is a Novel Indicator for Metabolic Syndrome
title Relative Children’s Lipid Accumulation Product Is a Novel Indicator for Metabolic Syndrome
title_full Relative Children’s Lipid Accumulation Product Is a Novel Indicator for Metabolic Syndrome
title_fullStr Relative Children’s Lipid Accumulation Product Is a Novel Indicator for Metabolic Syndrome
title_full_unstemmed Relative Children’s Lipid Accumulation Product Is a Novel Indicator for Metabolic Syndrome
title_short Relative Children’s Lipid Accumulation Product Is a Novel Indicator for Metabolic Syndrome
title_sort relative children’s lipid accumulation product is a novel indicator for metabolic syndrome
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173219/
https://www.ncbi.nlm.nih.gov/pubmed/34093432
http://dx.doi.org/10.3389/fendo.2021.645825
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