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Diagnosis and treatment of pediatric anaplastic lymphoma kinase-positive large B-cell lymphoma: A case report

BACKGROUND: Anaplastic lymphoma kinase-positive (ALK+) large B-cell lymphoma (LBCL) is a rare type of lymphoma with high invasiveness and rapid progression. It occurs in all age groups, but is extremely rare in children. The lesions mainly involve the lymph nodes and may present with extra-nodal inv...

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Autores principales: Zhang, Meng, Jin, Ling, Duan, Yan-Long, Yang, Jing, Huang, Shuang, Jin, Mei, Zhu, Guang-Hua, Gao, Chao, Liu, Yi, Zhang, Nan, Zhou, Chun-Ju, Gao, Zi-Fen, Zheng, Qin-Long, Chen, Dong, Zhang, Yong-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173411/
https://www.ncbi.nlm.nih.gov/pubmed/34141790
http://dx.doi.org/10.12998/wjcc.v9.i17.4268
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author Zhang, Meng
Jin, Ling
Duan, Yan-Long
Yang, Jing
Huang, Shuang
Jin, Mei
Zhu, Guang-Hua
Gao, Chao
Liu, Yi
Zhang, Nan
Zhou, Chun-Ju
Gao, Zi-Fen
Zheng, Qin-Long
Chen, Dong
Zhang, Yong-Hong
author_facet Zhang, Meng
Jin, Ling
Duan, Yan-Long
Yang, Jing
Huang, Shuang
Jin, Mei
Zhu, Guang-Hua
Gao, Chao
Liu, Yi
Zhang, Nan
Zhou, Chun-Ju
Gao, Zi-Fen
Zheng, Qin-Long
Chen, Dong
Zhang, Yong-Hong
author_sort Zhang, Meng
collection PubMed
description BACKGROUND: Anaplastic lymphoma kinase-positive (ALK+) large B-cell lymphoma (LBCL) is a rare type of lymphoma with high invasiveness and rapid progression. It occurs in all age groups, but is extremely rare in children. The lesions mainly involve the lymph nodes and may present with extra-nodal involvement. Response to conventional chemotherapies and local radiotherapy is poor, with a 5-year overall survival of less than 40%. Recently, the use of ALK inhibitors for the treatment of this disease has been reported. CASE SUMMARY: We present a case of a 12-year-old boy diagnosed with ALK+LBCL. The patient had a 2-mo medical history of a calvarial mass, extensive systemic involvement, and positive bone marrow clathrin heavy chain (CLTC)-ALK fusion gene. Complete remission 1 (CR1) was achieved using the modified LMB89 Group C regimen followed by autologous stem cell transplantation. The patient relapsed 3 mo later. He then achieved CR2 with three short courses of chemotherapy (COP, reduced-dose ICE, low-dose Ara-c+VP16) and continuous alectinib targeted therapy. Afterward, allogeneic hematopoietic stem cell transplantation (allo-HSCT) was performed. At 16 mo after the allo-HSCT, the patient was still in CR2. CONCLUSION: The modified LMB89 Group C regimen and ALK inhibitors are effective. Allo-HSCT should be performed after remission.
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spelling pubmed-81734112021-06-16 Diagnosis and treatment of pediatric anaplastic lymphoma kinase-positive large B-cell lymphoma: A case report Zhang, Meng Jin, Ling Duan, Yan-Long Yang, Jing Huang, Shuang Jin, Mei Zhu, Guang-Hua Gao, Chao Liu, Yi Zhang, Nan Zhou, Chun-Ju Gao, Zi-Fen Zheng, Qin-Long Chen, Dong Zhang, Yong-Hong World J Clin Cases Case Report BACKGROUND: Anaplastic lymphoma kinase-positive (ALK+) large B-cell lymphoma (LBCL) is a rare type of lymphoma with high invasiveness and rapid progression. It occurs in all age groups, but is extremely rare in children. The lesions mainly involve the lymph nodes and may present with extra-nodal involvement. Response to conventional chemotherapies and local radiotherapy is poor, with a 5-year overall survival of less than 40%. Recently, the use of ALK inhibitors for the treatment of this disease has been reported. CASE SUMMARY: We present a case of a 12-year-old boy diagnosed with ALK+LBCL. The patient had a 2-mo medical history of a calvarial mass, extensive systemic involvement, and positive bone marrow clathrin heavy chain (CLTC)-ALK fusion gene. Complete remission 1 (CR1) was achieved using the modified LMB89 Group C regimen followed by autologous stem cell transplantation. The patient relapsed 3 mo later. He then achieved CR2 with three short courses of chemotherapy (COP, reduced-dose ICE, low-dose Ara-c+VP16) and continuous alectinib targeted therapy. Afterward, allogeneic hematopoietic stem cell transplantation (allo-HSCT) was performed. At 16 mo after the allo-HSCT, the patient was still in CR2. CONCLUSION: The modified LMB89 Group C regimen and ALK inhibitors are effective. Allo-HSCT should be performed after remission. Baishideng Publishing Group Inc 2021-06-16 2021-06-16 /pmc/articles/PMC8173411/ /pubmed/34141790 http://dx.doi.org/10.12998/wjcc.v9.i17.4268 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Case Report
Zhang, Meng
Jin, Ling
Duan, Yan-Long
Yang, Jing
Huang, Shuang
Jin, Mei
Zhu, Guang-Hua
Gao, Chao
Liu, Yi
Zhang, Nan
Zhou, Chun-Ju
Gao, Zi-Fen
Zheng, Qin-Long
Chen, Dong
Zhang, Yong-Hong
Diagnosis and treatment of pediatric anaplastic lymphoma kinase-positive large B-cell lymphoma: A case report
title Diagnosis and treatment of pediatric anaplastic lymphoma kinase-positive large B-cell lymphoma: A case report
title_full Diagnosis and treatment of pediatric anaplastic lymphoma kinase-positive large B-cell lymphoma: A case report
title_fullStr Diagnosis and treatment of pediatric anaplastic lymphoma kinase-positive large B-cell lymphoma: A case report
title_full_unstemmed Diagnosis and treatment of pediatric anaplastic lymphoma kinase-positive large B-cell lymphoma: A case report
title_short Diagnosis and treatment of pediatric anaplastic lymphoma kinase-positive large B-cell lymphoma: A case report
title_sort diagnosis and treatment of pediatric anaplastic lymphoma kinase-positive large b-cell lymphoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173411/
https://www.ncbi.nlm.nih.gov/pubmed/34141790
http://dx.doi.org/10.12998/wjcc.v9.i17.4268
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