Cargando…

Bone marrow inhibition induced by azathioprine in a patient without mutation in the thiopurine S-methyltransferase pathogenic site: A case report

BACKGROUND: Azathioprine (AZA) and its close analog 6-mercaptopurine are thiopurines widely used in the treatment of patients with cancer, organ transplantation, and autoimmune or inflammatory diseases, including systemic lupus erythematosus. Bone marrow inhibition is a common side effect of AZA, an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Xiao-Shuang, Lu, Yuan-Yue, Gao, Yan-Fang, Shao, Wen, Yao, Jia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Baishideng Publishing Group Inc 2021
Materias:	Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173432/ https://www.ncbi.nlm.nih.gov/pubmed/34141785 http://dx.doi.org/10.12998/wjcc.v9.i17.4230

Ejemplares similares

Thiopurine S-Methyltransferase Polymorphisms Predict Hepatotoxicity in Azathioprine-Treated Patients with Autoimmune Diseases
por: Sheu, Heh-Shiang, et al.
Publicado: (2022)

Association of thiopurine S-methyltransferase and NUDT15 polymorphisms with azathioprine-induced myelotoxicity in Chinese patients with rheumatological disease
por: Su, Song-Sen, et al.
Publicado: (2020)

Association between Thiopurine S-Methyltransferase Polymorphisms and Azathioprine-Induced Adverse Drug Reactions in Patients with Autoimmune Diseases: A Meta-Analysis
por: Liu, Yue-Ping, et al.
Publicado: (2015)

Pharmacogenetics of thiopurine therapy: from thiopurine S-methyltransferase to S-adenosylmethionine
por: Mlinarič-Raščan, Irena, et al.
Publicado: (2009)

Normal Ranges of Thiopurine Methyltransferase Activity Do Not Affect Thioguanine Nucleotide Concentrations With Azathioprine Therapy in Inflammatory Bowel Disease
por: Jonason, David E, et al.
Publicado: (2020)

Thiopurine methyltransferase genotype and thiopurine S-methyltransferase activity in Greek children with inflammatory bowel disease
por: Gazouli, Μaria, et al.
Publicado: (2012)

Thiopurine Methyltransferase Activity and Thiopurine Metabolites in Inflammatory Bowel Disease
por: El-Matary, Wael
Publicado: (2020)

Pharmacogenetic studies of thiopurine methyltransferase genotype‐phenotype concordance and effect of methotrexate on thiopurine metabolism
por: Zimdahl Kahlin, Anna, et al.
Publicado: (2020)

Predicted expression of genes involved in the thiopurine metabolic pathway and azathioprine discontinuation due to myelotoxicity
por: Daniel, Laura L., et al.
Publicado: (2022)

Thiopurine methyltransferase genotype and activity cannot predict outcomes of azathioprine maintenance therapy for antineutrophil cytoplasmic antibody associated vasculitis: A retrospective cohort study
por: Hessels, Arno C., et al.
Publicado: (2018)

Thiopurine S-Methyltransferase and Methylenetetrahydrofolate Reductase Polymorphisms in Leukemia
por: KÜPELİ, Serhan
Publicado: (2015)

Thiopurine S-Methyltransferase Polymorphisms in Korean Dermatologic Patients
por: Lee, Minseok, et al.
Publicado: (2017)

Assessment of Thiopurine–based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia
por: Azimi, F, et al.
Publicado: (2014)

Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics
por: Lennard, Lynne, et al.
Publicado: (2014)

Usefulness of Measuring Thiopurine Metabolites in Children with Inflammatory Bowel Disease and Autoimmunological Hepatitis, Treated with Azathioprine
por: Bąk-Drabik, Katarzyna, et al.
Publicado: (2021)

Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression risk
por: Nguyen, Christine M., et al.
Publicado: (2011)

Polymorphisms of the thiopurine S-methyltransferase gene among the Libyan population
por: Zeglam, Hamza Ben, et al.
Publicado: (2015)

Thiopurine methyltransferase polymorphisms in children with acute lymphoblastic leukemia
por: Linga, Vijay Gandhi, et al.
Publicado: (2014)

Thiopurine S-methyltransferase activity in Nigerians: phenotypes and activity reference values
por: Adehin, Ayorinde, et al.
Publicado: (2018)

Thiopurine S-methyltransferase and Pemphigus Vulgaris: A Phenotype-Genotype Study
por: Mokhtari, Maral, et al.
Publicado: (2020)

Association between Thiopurine S-methyltransferase Polymorphisms and Thiopurine-Induced Adverse Drug Reactions in Patients with Inflammatory Bowel Disease: A Meta-Analysis
por: Liu, Yue-Ping, et al.
Publicado: (2015)

Scorpion primer PCR analysis for genotyping of allele variants of thiopurine s-methyltransferase*3
por: Yao, Pu, et al.
Publicado: (2020)

Thiopurine methyltransferase genotyping in Palestinian childhood acute lymphoblastic leukemia patients
por: Ayesh, Basim Mohammad, et al.
Publicado: (2013)

Genetic Polymorphism of Thiopurine S-methyltransferase in Children with Acute Lymphoblastic Leukemia in Jordan
por: Alsous, Mervat, et al.
Publicado: (2018)

The effect of azathioprine (Imuran) on the cell cycle of promonocytes and the production of monocytes in the bone marrow
Publicado: (1975)

Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods
por: Asadov, Chingiz, et al.
Publicado: (2017)

Molecular dynamics simulation of a human thiopurine S-methyltransferase complexed with 6-mercaptopurine model
por: Mokmak, Wanwimon, et al.
Publicado: (2009)

Thiopurine methyltransferase and treatment outcome in the UK acute lymphoblastic leukaemia trial ALL2003
por: Lennard, Lynne, et al.
Publicado: (2015)

Correlation between Thiopurine S-Methyltransferase Genotype and Adverse Events in Inflammatory Bowel Disease Patients
por: Ribaldone, Davide Giuseppe, et al.
Publicado: (2019)

Thiopurine S-methyltransferase genetic polymorphisms in adult patients with inflammatory bowel diseases in the Latvian population
por: Zalizko, Polina, et al.
Publicado: (2020)

Thiopurine Methyltransferase Predicts the Extent of Cytotoxicty and DNA Damage in Astroglial Cells after Thioguanine Exposure
por: Hosni-Ahmed, Amira, et al.
Publicado: (2011)

The Identification of a Novel Thiopurine S-Methyltransferase Allele, TPMT*45, in Korean Patient with Crohn’s Disease
por: Ha, Changhee, et al.
Publicado: (2020)

Pharmacogenetics of thiopurines
por: Franca, Raffaella, et al.
Publicado: (2019)

Azathioprine-Induced Marrow Suppression in Dermatology Patients - Analysis of 18 Patients
por: Saoji, Vikrant V, et al.
Publicado: (2022)

Clinical implication of thiopurine methyltransferase polymorphism in children with acute lymphoblastic leukemia: A preliminary Egyptian study
por: El-Rashedy, Farida H., et al.
Publicado: (2015)

Validation of New Allele-Specific Real-Time PCR System for Thiopurine Methyltransferase Genotyping in Korean Population
por: Kim, Sollip, et al.
Publicado: (2013)

Utilizing a user-centered approach to develop and assess pharmacogenomic clinical decision support for thiopurine methyltransferase
por: Nguyen, Khoa A., et al.
Publicado: (2019)

Thiopurines in Inflammatory Bowel Disease. How to Optimize Thiopurines in the Biologic Era?
por: Gargallo-Puyuelo, Carla J., et al.
Publicado: (2021)

Thiopurine S-methyltransferase polymorphisms in acute lymphoblastic leukemia, inflammatory bowel disease and autoimmune disorders: influence on treatment response
por: Abaji, Rachid, et al.
Publicado: (2017)

Impact of NUDT15 polymorphisms on thiopurines-induced myelotoxicity and thiopurines tolerance dose
por: Yin, Dandan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_bmqrosjeh695jcdktuh6uscoe4