Interleukins in cancer: from biology to therapy

Interleukins and associated cytokines serve as the means of communication for innate and adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a critical role in cancer development, progression and control. Interleukins can nurture an environment enabling and favouri...

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Autores principales: Briukhovetska, Daria, Dörr, Janina, Endres, Stefan, Libby, Peter, Dinarello, Charles A., Kobold, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173513/
https://www.ncbi.nlm.nih.gov/pubmed/34083781
http://dx.doi.org/10.1038/s41568-021-00363-z
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author Briukhovetska, Daria
Dörr, Janina
Endres, Stefan
Libby, Peter
Dinarello, Charles A.
Kobold, Sebastian
author_facet Briukhovetska, Daria
Dörr, Janina
Endres, Stefan
Libby, Peter
Dinarello, Charles A.
Kobold, Sebastian
author_sort Briukhovetska, Daria
collection PubMed
description Interleukins and associated cytokines serve as the means of communication for innate and adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a critical role in cancer development, progression and control. Interleukins can nurture an environment enabling and favouring cancer growth while simultaneously being essential for a productive tumour-directed immune response. These properties of interleukins can be exploited to improve immunotherapies to promote effectiveness as well as to limit side effects. This Review aims to unravel some of these complex interactions.
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spelling pubmed-81735132021-06-04 Interleukins in cancer: from biology to therapy Briukhovetska, Daria Dörr, Janina Endres, Stefan Libby, Peter Dinarello, Charles A. Kobold, Sebastian Nat Rev Cancer Review Article Interleukins and associated cytokines serve as the means of communication for innate and adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a critical role in cancer development, progression and control. Interleukins can nurture an environment enabling and favouring cancer growth while simultaneously being essential for a productive tumour-directed immune response. These properties of interleukins can be exploited to improve immunotherapies to promote effectiveness as well as to limit side effects. This Review aims to unravel some of these complex interactions. Nature Publishing Group UK 2021-06-03 2021 /pmc/articles/PMC8173513/ /pubmed/34083781 http://dx.doi.org/10.1038/s41568-021-00363-z Text en © Springer Nature Limited 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Briukhovetska, Daria
Dörr, Janina
Endres, Stefan
Libby, Peter
Dinarello, Charles A.
Kobold, Sebastian
Interleukins in cancer: from biology to therapy
title Interleukins in cancer: from biology to therapy
title_full Interleukins in cancer: from biology to therapy
title_fullStr Interleukins in cancer: from biology to therapy
title_full_unstemmed Interleukins in cancer: from biology to therapy
title_short Interleukins in cancer: from biology to therapy
title_sort interleukins in cancer: from biology to therapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173513/
https://www.ncbi.nlm.nih.gov/pubmed/34083781
http://dx.doi.org/10.1038/s41568-021-00363-z
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