Triphenylphosphine Oxide Removal from Reactions: The Role of Solvent and Temperature

[Image: see text] Here, a large-scale feasible, chromatography-free process to purge triphenylphosphine oxide (TPPO) from the crude product of Mitsunobu and Wittig reactions has been developed. Divergence in physicochemical properties like polarity and solubility of TPPO against the product was util...

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Detalles Bibliográficos
Autores principales: Tamboli, Yasinalli, Kashid, Bharat B., Yadav, Ram Prasad, Rafeeq, Mohammad, Yeole, Ravindra, Merwade, Arvind Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173612/
https://www.ncbi.nlm.nih.gov/pubmed/34095685
http://dx.doi.org/10.1021/acsomega.1c01996
Descripción
Sumario:[Image: see text] Here, a large-scale feasible, chromatography-free process to purge triphenylphosphine oxide (TPPO) from the crude product of Mitsunobu and Wittig reactions has been developed. Divergence in physicochemical properties like polarity and solubility of TPPO against the product was utilized to precipitate TPPO directly from the reaction mixture and eliminate by simple filtration on a kilogram scale at a pilot plant with high purity of the product.

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