Triphenylphosphine Oxide Removal from Reactions: The Role of Solvent and Temperature

[Image: see text] Here, a large-scale feasible, chromatography-free process to purge triphenylphosphine oxide (TPPO) from the crude product of Mitsunobu and Wittig reactions has been developed. Divergence in physicochemical properties like polarity and solubility of TPPO against the product was util...

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Autores principales: Tamboli, Yasinalli, Kashid, Bharat B., Yadav, Ram Prasad, Rafeeq, Mohammad, Yeole, Ravindra, Merwade, Arvind Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173612/
https://www.ncbi.nlm.nih.gov/pubmed/34095685
http://dx.doi.org/10.1021/acsomega.1c01996
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author Tamboli, Yasinalli
Kashid, Bharat B.
Yadav, Ram Prasad
Rafeeq, Mohammad
Yeole, Ravindra
Merwade, Arvind Y.
author_facet Tamboli, Yasinalli
Kashid, Bharat B.
Yadav, Ram Prasad
Rafeeq, Mohammad
Yeole, Ravindra
Merwade, Arvind Y.
author_sort Tamboli, Yasinalli
collection PubMed
description [Image: see text] Here, a large-scale feasible, chromatography-free process to purge triphenylphosphine oxide (TPPO) from the crude product of Mitsunobu and Wittig reactions has been developed. Divergence in physicochemical properties like polarity and solubility of TPPO against the product was utilized to precipitate TPPO directly from the reaction mixture and eliminate by simple filtration on a kilogram scale at a pilot plant with high purity of the product.
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spelling pubmed-81736122021-06-04 Triphenylphosphine Oxide Removal from Reactions: The Role of Solvent and Temperature Tamboli, Yasinalli Kashid, Bharat B. Yadav, Ram Prasad Rafeeq, Mohammad Yeole, Ravindra Merwade, Arvind Y. ACS Omega [Image: see text] Here, a large-scale feasible, chromatography-free process to purge triphenylphosphine oxide (TPPO) from the crude product of Mitsunobu and Wittig reactions has been developed. Divergence in physicochemical properties like polarity and solubility of TPPO against the product was utilized to precipitate TPPO directly from the reaction mixture and eliminate by simple filtration on a kilogram scale at a pilot plant with high purity of the product. American Chemical Society 2021-05-19 /pmc/articles/PMC8173612/ /pubmed/34095685 http://dx.doi.org/10.1021/acsomega.1c01996 Text en © 2021 The Authors. Published by American Chemical Society Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Tamboli, Yasinalli
Kashid, Bharat B.
Yadav, Ram Prasad
Rafeeq, Mohammad
Yeole, Ravindra
Merwade, Arvind Y.
Triphenylphosphine Oxide Removal from Reactions: The Role of Solvent and Temperature
title Triphenylphosphine Oxide Removal from Reactions: The Role of Solvent and Temperature
title_full Triphenylphosphine Oxide Removal from Reactions: The Role of Solvent and Temperature
title_fullStr Triphenylphosphine Oxide Removal from Reactions: The Role of Solvent and Temperature
title_full_unstemmed Triphenylphosphine Oxide Removal from Reactions: The Role of Solvent and Temperature
title_short Triphenylphosphine Oxide Removal from Reactions: The Role of Solvent and Temperature
title_sort triphenylphosphine oxide removal from reactions: the role of solvent and temperature
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173612/
https://www.ncbi.nlm.nih.gov/pubmed/34095685
http://dx.doi.org/10.1021/acsomega.1c01996
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