Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4(+) T cell perturbations

FOXP3 deficiency in mice and IPEX syndrome patients results in fatal autoimmunity by altering T regulatory cells (Treg). CD4(+) T cells in IPEX patients and Foxp3-deficient mice were analyzed by single-cell cytometry and RNAseq, revealing heterogeneous Treg-like cells, some very similar to normal Tr...

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Detalles Bibliográficos
Autores principales: Zemmour, David, Charbonnier, Louis-Marie, Leon, Juliette, Six, Emmanuelle, Keles, Sevgi, Delville, Marianne, Benamar, Mehdi, Baris, Safa, Zuber, Julien, Chen, Karin, Neven, Benedicte, Garcia-Lloret, Maria I., Ruemmele, Frank M., Brugnara, Carlo, Cerf-Bensussan, Nadine, Rieux-Laucat, Frederic, Cavazzana, Marina, André, Isabelle, Chatila, Talal A., Mathis, Diane, Benoist, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173714/
https://www.ncbi.nlm.nih.gov/pubmed/33833438
http://dx.doi.org/10.1038/s41590-021-00910-8

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