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Cost utility of fractional exhaled nitric oxide monitoring for the management of children asthma
INTRODUCTION: Fractional exhaled nitric oxide is a simple, non-invasive measurement of airway inflammation with minimal discomfort to the patient and with results available within a few minutes. This study aimed to evaluate the cost-effectiveness of asthma management using fractional exhaled nitric...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173882/ https://www.ncbi.nlm.nih.gov/pubmed/34082766 http://dx.doi.org/10.1186/s12962-021-00287-3 |
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author | Buendía, Jefferson Antonio Acuña-Cordero, Ranniery Rodriguez-Martinez, Carlos E. |
author_facet | Buendía, Jefferson Antonio Acuña-Cordero, Ranniery Rodriguez-Martinez, Carlos E. |
author_sort | Buendía, Jefferson Antonio |
collection | PubMed |
description | INTRODUCTION: Fractional exhaled nitric oxide is a simple, non-invasive measurement of airway inflammation with minimal discomfort to the patient and with results available within a few minutes. This study aimed to evaluate the cost-effectiveness of asthma management using fractional exhaled nitric oxide monitoring in patients between 4 and 18 years of age. METHODS: A Markov model was used to estimate the cost-utility of asthma management using fractional exhaled nitric oxide monitoring versus asthma management without using fractional exhaled nitric oxide monitoring (standard therapy) in patients between 4 and 18 years of age. Cost data were obtained from a retrospective study on asthma from a tertiary center, in Medellin, Colombia, while probabilities of the Markov model and utilities were obtained from the systematic review of published randomized clinical trials. The analysis was carried out from a societal perspective. RESULTS: The model showed that fractional exhaled nitric oxide monitoring was associated with a lower total cost than standard therapy (US $1333 vs. US $1452 average cost per patient) and higher QALYs (0.93 vs. 0.92 average per patient). The probability that fractional exhaled nitric oxide monitoring provides a more cost-effective use of resources compared with standard therapy exceeds 99% for all willingness-to-pay thresholds. CONCLUSION: Asthma management using fractional exhaled nitric oxide monitoring was cost-effective for treating patients between 4 and 18 years of age with mild to moderate allergic asthma. Our study suggests evidence that could be used by decision-makers to improve clinical practice guidelines, but this should be replicated in different clinical settings. |
format | Online Article Text |
id | pubmed-8173882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-81738822021-06-03 Cost utility of fractional exhaled nitric oxide monitoring for the management of children asthma Buendía, Jefferson Antonio Acuña-Cordero, Ranniery Rodriguez-Martinez, Carlos E. Cost Eff Resour Alloc Research INTRODUCTION: Fractional exhaled nitric oxide is a simple, non-invasive measurement of airway inflammation with minimal discomfort to the patient and with results available within a few minutes. This study aimed to evaluate the cost-effectiveness of asthma management using fractional exhaled nitric oxide monitoring in patients between 4 and 18 years of age. METHODS: A Markov model was used to estimate the cost-utility of asthma management using fractional exhaled nitric oxide monitoring versus asthma management without using fractional exhaled nitric oxide monitoring (standard therapy) in patients between 4 and 18 years of age. Cost data were obtained from a retrospective study on asthma from a tertiary center, in Medellin, Colombia, while probabilities of the Markov model and utilities were obtained from the systematic review of published randomized clinical trials. The analysis was carried out from a societal perspective. RESULTS: The model showed that fractional exhaled nitric oxide monitoring was associated with a lower total cost than standard therapy (US $1333 vs. US $1452 average cost per patient) and higher QALYs (0.93 vs. 0.92 average per patient). The probability that fractional exhaled nitric oxide monitoring provides a more cost-effective use of resources compared with standard therapy exceeds 99% for all willingness-to-pay thresholds. CONCLUSION: Asthma management using fractional exhaled nitric oxide monitoring was cost-effective for treating patients between 4 and 18 years of age with mild to moderate allergic asthma. Our study suggests evidence that could be used by decision-makers to improve clinical practice guidelines, but this should be replicated in different clinical settings. BioMed Central 2021-06-03 /pmc/articles/PMC8173882/ /pubmed/34082766 http://dx.doi.org/10.1186/s12962-021-00287-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Buendía, Jefferson Antonio Acuña-Cordero, Ranniery Rodriguez-Martinez, Carlos E. Cost utility of fractional exhaled nitric oxide monitoring for the management of children asthma |
title | Cost utility of fractional exhaled nitric oxide monitoring for the management of children asthma |
title_full | Cost utility of fractional exhaled nitric oxide monitoring for the management of children asthma |
title_fullStr | Cost utility of fractional exhaled nitric oxide monitoring for the management of children asthma |
title_full_unstemmed | Cost utility of fractional exhaled nitric oxide monitoring for the management of children asthma |
title_short | Cost utility of fractional exhaled nitric oxide monitoring for the management of children asthma |
title_sort | cost utility of fractional exhaled nitric oxide monitoring for the management of children asthma |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173882/ https://www.ncbi.nlm.nih.gov/pubmed/34082766 http://dx.doi.org/10.1186/s12962-021-00287-3 |
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