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The heterogeneous human memory CCR6+ T helper-17 populations differ in T-bet and cytokine expression but all activate synovial fibroblasts in an IFNγ-independent manner
BACKGROUND: Chronic synovial inflammation is an important hallmark of inflammatory arthritis, but the cells and mechanisms involved are incompletely understood. Previously, we have shown that CCR6+ memory T-helper (memTh) cells and synovial fibroblasts (SF) activate each other in a pro-inflammatory...
Autores principales: | Dankers, Wendy, den Braanker, Hannah, Paulissen, Sandra M. J., van Hamburg, Jan Piet, Davelaar, Nadine, Colin, Edgar M., Lubberts, Erik |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173960/ https://www.ncbi.nlm.nih.gov/pubmed/34082814 http://dx.doi.org/10.1186/s13075-021-02532-9 |
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