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Investigating Dual-Energy CT Post-Contrast Phases for Liver Iron Quantification: A Preliminary Study

BACKGROUND AND PURPOSE: Quantification of hepatic virtual iron content (VIC) by using Multidetector Dual Energy Computed Tomography (DECT) has been recently investigated since this technique could offer a good compromise between accuracy and non-invasiveness for liver iron content quantification. Th...

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Autores principales: Basso, Luca, Baldi, Dario, Mannelli, Lorenzo, Cavaliere, Carlo, Salvatore, Marco, Brancato, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173994/
https://www.ncbi.nlm.nih.gov/pubmed/34121963
http://dx.doi.org/10.1177/15593258211011359
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author Basso, Luca
Baldi, Dario
Mannelli, Lorenzo
Cavaliere, Carlo
Salvatore, Marco
Brancato, Valentina
author_facet Basso, Luca
Baldi, Dario
Mannelli, Lorenzo
Cavaliere, Carlo
Salvatore, Marco
Brancato, Valentina
author_sort Basso, Luca
collection PubMed
description BACKGROUND AND PURPOSE: Quantification of hepatic virtual iron content (VIC) by using Multidetector Dual Energy Computed Tomography (DECT) has been recently investigated since this technique could offer a good compromise between accuracy and non-invasiveness for liver iron content quantification. The aim of our study is to investigate differences in VIC at different DECT time points (namely baseline and arterial, venous and tardive phases), identifying the most reliable and also exploring the underlying temporal trend of these values. MATERIALS AND METHODS: Eleven patients who underwent DECT examination and were characterized by low liver fat content were included in this retrospective study. By using the Syngo.via Frontier–DE IronVNC tool, regions of interest (ROI) were placed on the VIC images at 3 hepatic levels, both in left and right liver lobes, at each DECT time point. Friedman’s test followed by Bonferroni-adjusted Wilcoxon signed-rank test for post-hoc analysis was performed to assess differences between DECT timepoints. Page’s L test was performed to test the temporal trend of VIC across the 4 examined timepoints. RESULTS: For both liver lobes, Friedman’s test followed by Bonferroni-adjusted Wilcoxon signed-rank test revealed that VIC values differed significantly when extracted from ROIs placed at the 4 different timepoints. The Page’s L test for multiple comparison revealed a significant growing trend for VIC, from baseline acquisition to the fourth and last time point post-contrast agent injection. CONCLUSIONS: The extraction of hepatic VIC in healthy subjects was found to be significantly influenced by the DECT time point chosen for the extrapolation of the VIC values.
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spelling pubmed-81739942021-06-10 Investigating Dual-Energy CT Post-Contrast Phases for Liver Iron Quantification: A Preliminary Study Basso, Luca Baldi, Dario Mannelli, Lorenzo Cavaliere, Carlo Salvatore, Marco Brancato, Valentina Dose Response State of the Art CT and Image Quality, Radiation, and Contrast Dose BACKGROUND AND PURPOSE: Quantification of hepatic virtual iron content (VIC) by using Multidetector Dual Energy Computed Tomography (DECT) has been recently investigated since this technique could offer a good compromise between accuracy and non-invasiveness for liver iron content quantification. The aim of our study is to investigate differences in VIC at different DECT time points (namely baseline and arterial, venous and tardive phases), identifying the most reliable and also exploring the underlying temporal trend of these values. MATERIALS AND METHODS: Eleven patients who underwent DECT examination and were characterized by low liver fat content were included in this retrospective study. By using the Syngo.via Frontier–DE IronVNC tool, regions of interest (ROI) were placed on the VIC images at 3 hepatic levels, both in left and right liver lobes, at each DECT time point. Friedman’s test followed by Bonferroni-adjusted Wilcoxon signed-rank test for post-hoc analysis was performed to assess differences between DECT timepoints. Page’s L test was performed to test the temporal trend of VIC across the 4 examined timepoints. RESULTS: For both liver lobes, Friedman’s test followed by Bonferroni-adjusted Wilcoxon signed-rank test revealed that VIC values differed significantly when extracted from ROIs placed at the 4 different timepoints. The Page’s L test for multiple comparison revealed a significant growing trend for VIC, from baseline acquisition to the fourth and last time point post-contrast agent injection. CONCLUSIONS: The extraction of hepatic VIC in healthy subjects was found to be significantly influenced by the DECT time point chosen for the extrapolation of the VIC values. SAGE Publications 2021-06-01 /pmc/articles/PMC8173994/ /pubmed/34121963 http://dx.doi.org/10.1177/15593258211011359 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle State of the Art CT and Image Quality, Radiation, and Contrast Dose
Basso, Luca
Baldi, Dario
Mannelli, Lorenzo
Cavaliere, Carlo
Salvatore, Marco
Brancato, Valentina
Investigating Dual-Energy CT Post-Contrast Phases for Liver Iron Quantification: A Preliminary Study
title Investigating Dual-Energy CT Post-Contrast Phases for Liver Iron Quantification: A Preliminary Study
title_full Investigating Dual-Energy CT Post-Contrast Phases for Liver Iron Quantification: A Preliminary Study
title_fullStr Investigating Dual-Energy CT Post-Contrast Phases for Liver Iron Quantification: A Preliminary Study
title_full_unstemmed Investigating Dual-Energy CT Post-Contrast Phases for Liver Iron Quantification: A Preliminary Study
title_short Investigating Dual-Energy CT Post-Contrast Phases for Liver Iron Quantification: A Preliminary Study
title_sort investigating dual-energy ct post-contrast phases for liver iron quantification: a preliminary study
topic State of the Art CT and Image Quality, Radiation, and Contrast Dose
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173994/
https://www.ncbi.nlm.nih.gov/pubmed/34121963
http://dx.doi.org/10.1177/15593258211011359
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