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Zebrafish as a Translational Model: An Experimental Alternative to Study the Mechanisms Involved in Anosmia and Possible Neurodegenerative Aspects of COVID-19?

The Coronavirus disease-2019 (COVID-19) presents a variability of clinical symptoms, ranging from asymptomatic to severe respiratory and systemic conditions. In a cohort of patients, the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), beyond the classical respiratory manifestations, indu...

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Autores principales: Costa, Karla C. M., Brigante, Tamires A. V., Fernandes, Gabriel G., Scomparin, Davi S., Scarante, Franciele F., de Oliveira, Danielle P., Campos, Alline C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174008/
https://www.ncbi.nlm.nih.gov/pubmed/33952614
http://dx.doi.org/10.1523/ENEURO.0027-21.2021
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author Costa, Karla C. M.
Brigante, Tamires A. V.
Fernandes, Gabriel G.
Scomparin, Davi S.
Scarante, Franciele F.
de Oliveira, Danielle P.
Campos, Alline C.
author_facet Costa, Karla C. M.
Brigante, Tamires A. V.
Fernandes, Gabriel G.
Scomparin, Davi S.
Scarante, Franciele F.
de Oliveira, Danielle P.
Campos, Alline C.
author_sort Costa, Karla C. M.
collection PubMed
description The Coronavirus disease-2019 (COVID-19) presents a variability of clinical symptoms, ranging from asymptomatic to severe respiratory and systemic conditions. In a cohort of patients, the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), beyond the classical respiratory manifestations, induces anosmia. Evidence has suggested SARS-CoV-2-induced anosmia can be the result of neurodegeneration of the olfactory pathway. Neurologic symptoms associated with COVID-19 have been reported; however, the precise mechanism and possible long-lasting effects remain poorly investigated. Preclinical models are valuable tools for describing and testing new possible treatments for neurologic disorders. In this way, the zebrafish (Danio rerio) organism model represents an attractive tool in the field of neuroscience, showing economic and logistic advantages besides genetic and physiologic similarities with mammalian, including the brain structure and functions. Besides, its external embryonic development, high availability of eggs, and fast development allows easy genetic manipulation and fast replications. In the present review, we suggest that the zebrafish model can be advantageous to investigate the neurologic features of COVID-19.
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spelling pubmed-81740082021-06-03 Zebrafish as a Translational Model: An Experimental Alternative to Study the Mechanisms Involved in Anosmia and Possible Neurodegenerative Aspects of COVID-19? Costa, Karla C. M. Brigante, Tamires A. V. Fernandes, Gabriel G. Scomparin, Davi S. Scarante, Franciele F. de Oliveira, Danielle P. Campos, Alline C. eNeuro Review The Coronavirus disease-2019 (COVID-19) presents a variability of clinical symptoms, ranging from asymptomatic to severe respiratory and systemic conditions. In a cohort of patients, the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), beyond the classical respiratory manifestations, induces anosmia. Evidence has suggested SARS-CoV-2-induced anosmia can be the result of neurodegeneration of the olfactory pathway. Neurologic symptoms associated with COVID-19 have been reported; however, the precise mechanism and possible long-lasting effects remain poorly investigated. Preclinical models are valuable tools for describing and testing new possible treatments for neurologic disorders. In this way, the zebrafish (Danio rerio) organism model represents an attractive tool in the field of neuroscience, showing economic and logistic advantages besides genetic and physiologic similarities with mammalian, including the brain structure and functions. Besides, its external embryonic development, high availability of eggs, and fast development allows easy genetic manipulation and fast replications. In the present review, we suggest that the zebrafish model can be advantageous to investigate the neurologic features of COVID-19. Society for Neuroscience 2021-05-28 /pmc/articles/PMC8174008/ /pubmed/33952614 http://dx.doi.org/10.1523/ENEURO.0027-21.2021 Text en Copyright © 2021 Costa et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review
Costa, Karla C. M.
Brigante, Tamires A. V.
Fernandes, Gabriel G.
Scomparin, Davi S.
Scarante, Franciele F.
de Oliveira, Danielle P.
Campos, Alline C.
Zebrafish as a Translational Model: An Experimental Alternative to Study the Mechanisms Involved in Anosmia and Possible Neurodegenerative Aspects of COVID-19?
title Zebrafish as a Translational Model: An Experimental Alternative to Study the Mechanisms Involved in Anosmia and Possible Neurodegenerative Aspects of COVID-19?
title_full Zebrafish as a Translational Model: An Experimental Alternative to Study the Mechanisms Involved in Anosmia and Possible Neurodegenerative Aspects of COVID-19?
title_fullStr Zebrafish as a Translational Model: An Experimental Alternative to Study the Mechanisms Involved in Anosmia and Possible Neurodegenerative Aspects of COVID-19?
title_full_unstemmed Zebrafish as a Translational Model: An Experimental Alternative to Study the Mechanisms Involved in Anosmia and Possible Neurodegenerative Aspects of COVID-19?
title_short Zebrafish as a Translational Model: An Experimental Alternative to Study the Mechanisms Involved in Anosmia and Possible Neurodegenerative Aspects of COVID-19?
title_sort zebrafish as a translational model: an experimental alternative to study the mechanisms involved in anosmia and possible neurodegenerative aspects of covid-19?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174008/
https://www.ncbi.nlm.nih.gov/pubmed/33952614
http://dx.doi.org/10.1523/ENEURO.0027-21.2021
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