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IGF1-Stimulated Posttraumatic Hippocampal Remodeling Is Not Dependent on mTOR

Adult hippocampal neurogenesis is stimulated acutely following traumatic brain injury (TBI). However, many hippocampal neurons born after injury develop abnormally and the number that survive long-term is debated. In experimental TBI, insulin-like growth factor-1 (IGF1) promotes hippocampal neuronal...

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Detalles Bibliográficos
Autores principales: Littlejohn, Erica L., DeSana, Anthony J., Williams, Hannah C., Chapman, Rudy T., Joseph, Binoy, Juras, Jelena A., Saatman, Kathryn E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174097/
https://www.ncbi.nlm.nih.gov/pubmed/34095131
http://dx.doi.org/10.3389/fcell.2021.663456