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手术前后血清LDH浓度与大细胞神经内分泌肺癌患者手术预后的相关性分析
BACKGROUND AND OBJECTIVE: Studies have shown that elevated serum lactate dehydrogenase (LDH) concentration can lead to poor prognosis in patients with small cell lung cancer and lung adenocarcinoma, but its relationship with the prognosis of patients with lung large-cell neuroendocrine carcinoma (L-...
Formato: | Online Artículo Texto |
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Lenguaje: | English |
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中国肺癌杂志编辑部
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174107/ https://www.ncbi.nlm.nih.gov/pubmed/34034459 http://dx.doi.org/10.3779/j.issn.1009-3419.2021.103.01 |
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collection | PubMed |
description | BACKGROUND AND OBJECTIVE: Studies have shown that elevated serum lactate dehydrogenase (LDH) concentration can lead to poor prognosis in patients with small cell lung cancer and lung adenocarcinoma, but its relationship with the prognosis of patients with lung large-cell neuroendocrine carcinoma (L-LCNEC) is not clear. This study aims to explore the influence of L-LCNEC preoperative serum LDH concentration and postoperative LDH concentration change trend on the disease-free survival (DFS) of patients after surgery, so as to judge the clinical prognosis of L-LCNEC provides new ideas. METHODS: Collected the clinical data. The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value, while the Kaplan-Meier and Cox proportional hazard model were used to analyze data. RESULTS: DFS was shortened in patients with high serum LDH concentration before operation and increased LDH concentration after operation (P < 0.001, P < 0.001). The preoperative LDH concentration and postoperative LDH concentration change trend were independent prognostic factors for patients (P < 0.001, P=0.037). CONCLUSION: Preoperative LDH concentration and its postoperative concentration change trend in patients with L-LCNEC are independent prognostic factors for DFS of patients. |
format | Online Article Text |
id | pubmed-8174107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | 中国肺癌杂志编辑部 |
record_format | MEDLINE/PubMed |
spelling | pubmed-81741072021-06-17 手术前后血清LDH浓度与大细胞神经内分泌肺癌患者手术预后的相关性分析 Zhongguo Fei Ai Za Zhi 临床研究 BACKGROUND AND OBJECTIVE: Studies have shown that elevated serum lactate dehydrogenase (LDH) concentration can lead to poor prognosis in patients with small cell lung cancer and lung adenocarcinoma, but its relationship with the prognosis of patients with lung large-cell neuroendocrine carcinoma (L-LCNEC) is not clear. This study aims to explore the influence of L-LCNEC preoperative serum LDH concentration and postoperative LDH concentration change trend on the disease-free survival (DFS) of patients after surgery, so as to judge the clinical prognosis of L-LCNEC provides new ideas. METHODS: Collected the clinical data. The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value, while the Kaplan-Meier and Cox proportional hazard model were used to analyze data. RESULTS: DFS was shortened in patients with high serum LDH concentration before operation and increased LDH concentration after operation (P < 0.001, P < 0.001). The preoperative LDH concentration and postoperative LDH concentration change trend were independent prognostic factors for patients (P < 0.001, P=0.037). CONCLUSION: Preoperative LDH concentration and its postoperative concentration change trend in patients with L-LCNEC are independent prognostic factors for DFS of patients. 中国肺癌杂志编辑部 2021-05-20 /pmc/articles/PMC8174107/ /pubmed/34034459 http://dx.doi.org/10.3779/j.issn.1009-3419.2021.103.01 Text en 版权所有©《中国肺癌杂志》编辑部2021 https://creativecommons.org/licenses/by/3.0/This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/. |
spellingShingle | 临床研究 手术前后血清LDH浓度与大细胞神经内分泌肺癌患者手术预后的相关性分析 |
title | 手术前后血清LDH浓度与大细胞神经内分泌肺癌患者手术预后的相关性分析 |
title_full | 手术前后血清LDH浓度与大细胞神经内分泌肺癌患者手术预后的相关性分析 |
title_fullStr | 手术前后血清LDH浓度与大细胞神经内分泌肺癌患者手术预后的相关性分析 |
title_full_unstemmed | 手术前后血清LDH浓度与大细胞神经内分泌肺癌患者手术预后的相关性分析 |
title_short | 手术前后血清LDH浓度与大细胞神经内分泌肺癌患者手术预后的相关性分析 |
title_sort | 手术前后血清ldh浓度与大细胞神经内分泌肺癌患者手术预后的相关性分析 |
topic | 临床研究 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174107/ https://www.ncbi.nlm.nih.gov/pubmed/34034459 http://dx.doi.org/10.3779/j.issn.1009-3419.2021.103.01 |
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