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Pulmonary parenchymal involvement caused by Tropheryma whipplei
We report a 26-year-old man with left chest pain for 4 days. His chest CT showed a cavity in the left upper lung. Tuberculosis was suspected first, but metagenomics next generation sequencing (mNGS) in bronchoalveolar lavage fluid only detected Tropheryma whipplei. Tropheryma whipplei is the pathoge...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174119/ https://www.ncbi.nlm.nih.gov/pubmed/34131590 http://dx.doi.org/10.1515/med-2021-0297 |
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author | Zhang, Wen Mei Xu, Ling |
author_facet | Zhang, Wen Mei Xu, Ling |
author_sort | Zhang, Wen Mei |
collection | PubMed |
description | We report a 26-year-old man with left chest pain for 4 days. His chest CT showed a cavity in the left upper lung. Tuberculosis was suspected first, but metagenomics next generation sequencing (mNGS) in bronchoalveolar lavage fluid only detected Tropheryma whipplei. Tropheryma whipplei is the pathogen of Whipple’s disease. The most frequently involved organs are the eyes, heart, and central nervous system. Pulmonary parenchymal involvement is rare. To our knowledge, this is the first reported case of pulmonary cavity caused by Tropheryma whipplei. Nineteen cases of pulmonary parenchymal involvement were found by literature search. The most common respiratory symptom was cough, followed by dyspnea/breathlessness and chest pain. The most common finding in chest imaging was pulmonary nodules, followed by interstitial changes and patchy infiltration. Our case and literature review highlighted that Tropheryma whipplei infection should be considered in the differential diagnosis of pulmonary cavity, pulmonary nodules, interstitial changes, and patchy infiltration. mNGS is helpful to improve diagnosis rate. |
format | Online Article Text |
id | pubmed-8174119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-81741192021-06-14 Pulmonary parenchymal involvement caused by Tropheryma whipplei Zhang, Wen Mei Xu, Ling Open Med (Wars) Case Report We report a 26-year-old man with left chest pain for 4 days. His chest CT showed a cavity in the left upper lung. Tuberculosis was suspected first, but metagenomics next generation sequencing (mNGS) in bronchoalveolar lavage fluid only detected Tropheryma whipplei. Tropheryma whipplei is the pathogen of Whipple’s disease. The most frequently involved organs are the eyes, heart, and central nervous system. Pulmonary parenchymal involvement is rare. To our knowledge, this is the first reported case of pulmonary cavity caused by Tropheryma whipplei. Nineteen cases of pulmonary parenchymal involvement were found by literature search. The most common respiratory symptom was cough, followed by dyspnea/breathlessness and chest pain. The most common finding in chest imaging was pulmonary nodules, followed by interstitial changes and patchy infiltration. Our case and literature review highlighted that Tropheryma whipplei infection should be considered in the differential diagnosis of pulmonary cavity, pulmonary nodules, interstitial changes, and patchy infiltration. mNGS is helpful to improve diagnosis rate. De Gruyter 2021-06-02 /pmc/articles/PMC8174119/ /pubmed/34131590 http://dx.doi.org/10.1515/med-2021-0297 Text en © 2021 Wen Mei Zhang and Ling Xu, published by De Gruyter https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. |
spellingShingle | Case Report Zhang, Wen Mei Xu, Ling Pulmonary parenchymal involvement caused by Tropheryma whipplei |
title | Pulmonary parenchymal involvement caused by Tropheryma whipplei
|
title_full | Pulmonary parenchymal involvement caused by Tropheryma whipplei
|
title_fullStr | Pulmonary parenchymal involvement caused by Tropheryma whipplei
|
title_full_unstemmed | Pulmonary parenchymal involvement caused by Tropheryma whipplei
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title_short | Pulmonary parenchymal involvement caused by Tropheryma whipplei
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title_sort | pulmonary parenchymal involvement caused by tropheryma whipplei |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174119/ https://www.ncbi.nlm.nih.gov/pubmed/34131590 http://dx.doi.org/10.1515/med-2021-0297 |
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