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Association of Pro‐B‐Type Natriuretic Peptide With Cardiac Magnetic Resonance–Measured Global and Regional Cardiac Function and Structure Over 10 Years: The MESA Study
BACKGROUND: NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) is widely used to diagnose and manage patients with heart failure. We aimed to investigate associations between NT‐proBNP levels and development of global and regional myocardial impairment, dyssynchrony, and risk of developing myocar...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174164/ https://www.ncbi.nlm.nih.gov/pubmed/33821688 http://dx.doi.org/10.1161/JAHA.120.019243 |
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author | Rahsepar, Amir Ali Bluemke, David A. Habibi, Mohammadali Liu, Kiang Kawel‐Boehm, Nadine Ambale‐Venkatesh, Bharath Fernandes, Veronica R. S. Rosen, Boaz D. Lima, Joao A. C. Carr, James C. |
author_facet | Rahsepar, Amir Ali Bluemke, David A. Habibi, Mohammadali Liu, Kiang Kawel‐Boehm, Nadine Ambale‐Venkatesh, Bharath Fernandes, Veronica R. S. Rosen, Boaz D. Lima, Joao A. C. Carr, James C. |
author_sort | Rahsepar, Amir Ali |
collection | PubMed |
description | BACKGROUND: NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) is widely used to diagnose and manage patients with heart failure. We aimed to investigate associations between NT‐proBNP levels and development of global and regional myocardial impairment, dyssynchrony, and risk of developing myocardial scar over time. METHODS AND RESULTS: We included 2416 adults (45–84 years) without baseline clinical cardiovascular disease from MESA (Multi‐Ethnic Study of Atherosclerosis). NT‐proBNP was assessed at baseline (2000–2002). Cardiac magnetic resonance–measured left ventricular parameters were assessed at baseline and year 10 (2010–2012). Tagged cardiac magnetic resonance and myocardial dyssynchrony were assessed. We used linear and logistic regression models to study the relationships between quartiles of NT‐proBNP levels and outcome variables. Left ventricular parameters decreased over time. After 10‐year follow‐up and adjusting for cardiovascular disease risk factors, people in the highest quartile had significantly greater decline in left ventricular ejection fraction (−1.60%; 95% CI, −2.26 to −0.94; P<0.01) and smaller decline in left ventricular end systolic volume index (−0.47 mL/m(2); 95% CI, −1.18 to 0.23; P<0.01) compared with those in the lowest quartile. Individuals in the highest quartile had more severe risk factor adjusted global, mid, and apical regional dyssynchrony compared with those in the lowest, second, and third quartiles (all P‐trend<0.05). Compared with the lowest‐quartile group, the adjusted odds ratios for having myocardial scar was 1.3 (95% CI, 0.7–2.2) for quartile 2; 1.2 (95% CI, 0.6–2.3) for quartile 3; and 2.7 (95% CI, 1.4–5.5) for quartile 4 (P‐trend=0.012) for the total sample. CONCLUSIONS: Among participants without baseline clinical cardiovascular disease, higher baseline NT‐proBNP concentration was significantly associated with subclinical changes in developing myocardial dysfunction, more severe cardiac dyssynchrony, and higher odds of having myocardial scar over a 10‐year period independent of traditional cardiovascular disease risk factors. |
format | Online Article Text |
id | pubmed-8174164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81741642021-06-11 Association of Pro‐B‐Type Natriuretic Peptide With Cardiac Magnetic Resonance–Measured Global and Regional Cardiac Function and Structure Over 10 Years: The MESA Study Rahsepar, Amir Ali Bluemke, David A. Habibi, Mohammadali Liu, Kiang Kawel‐Boehm, Nadine Ambale‐Venkatesh, Bharath Fernandes, Veronica R. S. Rosen, Boaz D. Lima, Joao A. C. Carr, James C. J Am Heart Assoc Original Research BACKGROUND: NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) is widely used to diagnose and manage patients with heart failure. We aimed to investigate associations between NT‐proBNP levels and development of global and regional myocardial impairment, dyssynchrony, and risk of developing myocardial scar over time. METHODS AND RESULTS: We included 2416 adults (45–84 years) without baseline clinical cardiovascular disease from MESA (Multi‐Ethnic Study of Atherosclerosis). NT‐proBNP was assessed at baseline (2000–2002). Cardiac magnetic resonance–measured left ventricular parameters were assessed at baseline and year 10 (2010–2012). Tagged cardiac magnetic resonance and myocardial dyssynchrony were assessed. We used linear and logistic regression models to study the relationships between quartiles of NT‐proBNP levels and outcome variables. Left ventricular parameters decreased over time. After 10‐year follow‐up and adjusting for cardiovascular disease risk factors, people in the highest quartile had significantly greater decline in left ventricular ejection fraction (−1.60%; 95% CI, −2.26 to −0.94; P<0.01) and smaller decline in left ventricular end systolic volume index (−0.47 mL/m(2); 95% CI, −1.18 to 0.23; P<0.01) compared with those in the lowest quartile. Individuals in the highest quartile had more severe risk factor adjusted global, mid, and apical regional dyssynchrony compared with those in the lowest, second, and third quartiles (all P‐trend<0.05). Compared with the lowest‐quartile group, the adjusted odds ratios for having myocardial scar was 1.3 (95% CI, 0.7–2.2) for quartile 2; 1.2 (95% CI, 0.6–2.3) for quartile 3; and 2.7 (95% CI, 1.4–5.5) for quartile 4 (P‐trend=0.012) for the total sample. CONCLUSIONS: Among participants without baseline clinical cardiovascular disease, higher baseline NT‐proBNP concentration was significantly associated with subclinical changes in developing myocardial dysfunction, more severe cardiac dyssynchrony, and higher odds of having myocardial scar over a 10‐year period independent of traditional cardiovascular disease risk factors. John Wiley and Sons Inc. 2021-04-06 /pmc/articles/PMC8174164/ /pubmed/33821688 http://dx.doi.org/10.1161/JAHA.120.019243 Text en © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Research Rahsepar, Amir Ali Bluemke, David A. Habibi, Mohammadali Liu, Kiang Kawel‐Boehm, Nadine Ambale‐Venkatesh, Bharath Fernandes, Veronica R. S. Rosen, Boaz D. Lima, Joao A. C. Carr, James C. Association of Pro‐B‐Type Natriuretic Peptide With Cardiac Magnetic Resonance–Measured Global and Regional Cardiac Function and Structure Over 10 Years: The MESA Study |
title | Association of Pro‐B‐Type Natriuretic Peptide With Cardiac Magnetic Resonance–Measured Global and Regional Cardiac Function and Structure Over 10 Years: The MESA Study |
title_full | Association of Pro‐B‐Type Natriuretic Peptide With Cardiac Magnetic Resonance–Measured Global and Regional Cardiac Function and Structure Over 10 Years: The MESA Study |
title_fullStr | Association of Pro‐B‐Type Natriuretic Peptide With Cardiac Magnetic Resonance–Measured Global and Regional Cardiac Function and Structure Over 10 Years: The MESA Study |
title_full_unstemmed | Association of Pro‐B‐Type Natriuretic Peptide With Cardiac Magnetic Resonance–Measured Global and Regional Cardiac Function and Structure Over 10 Years: The MESA Study |
title_short | Association of Pro‐B‐Type Natriuretic Peptide With Cardiac Magnetic Resonance–Measured Global and Regional Cardiac Function and Structure Over 10 Years: The MESA Study |
title_sort | association of pro‐b‐type natriuretic peptide with cardiac magnetic resonance–measured global and regional cardiac function and structure over 10 years: the mesa study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174164/ https://www.ncbi.nlm.nih.gov/pubmed/33821688 http://dx.doi.org/10.1161/JAHA.120.019243 |
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