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Prospective Study on Plasma MicroRNA‐4286 and Incident Acute Coronary Syndrome
BACKGROUND: Mounting evidence suggests that circulating microRNAs (miRNAs) are critical indicators of cardiovascular disease. However, prospective studies linking circulating miRNAs to incident acute coronary syndrome (ACS) are limited, and the underlying effect of associated miRNA on incident ACS r...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174203/ https://www.ncbi.nlm.nih.gov/pubmed/33719498 http://dx.doi.org/10.1161/JAHA.120.018999 |
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author | Shen, Miaoyan Xu, Xuedan Liu, Xuezhen Wang, Qiuhong Li, Wending You, Xiaomin Peng, Rong Yuan, Yu Long, Pinpin Niu, Rundong Yang, Handong Cheng, Xiang Pan, An Tanguay, Robert M. Zhang, Xiaomin He, Meian Wang, Chaolong Liang, Liming Wu, Tangchun |
author_facet | Shen, Miaoyan Xu, Xuedan Liu, Xuezhen Wang, Qiuhong Li, Wending You, Xiaomin Peng, Rong Yuan, Yu Long, Pinpin Niu, Rundong Yang, Handong Cheng, Xiang Pan, An Tanguay, Robert M. Zhang, Xiaomin He, Meian Wang, Chaolong Liang, Liming Wu, Tangchun |
author_sort | Shen, Miaoyan |
collection | PubMed |
description | BACKGROUND: Mounting evidence suggests that circulating microRNAs (miRNAs) are critical indicators of cardiovascular disease. However, prospective studies linking circulating miRNAs to incident acute coronary syndrome (ACS) are limited, and the underlying effect of associated miRNA on incident ACS remains unknown. METHODS AND RESULTS: Based on a 2‐stage prospective nested case–control design within the Dongfeng‐Tongji cohort, we profiled plasma miRNAs from 23 pairs of incident ACS cases and controls by microarray and validated the candidate miRNAs in 572 incident ACS case–control pairs using quantitative real‐time polymerase chain reaction. We observed that plasma miR‐4286 was associated with higher risk of ACS (adjusted odds ratio according to an interquartile range increase, 1.26 [95% CI, 1.07–1.48]). Further association analysis revealed that triglyceride was positively associated with plasma miR‐4286, and an interquartile range increase in triglyceride was associated with an 11.04% (95% CI, 3.77%–18.83%) increase in plasma miR‐4286. In addition, the Mendelian randomization analysis suggested a potential causal effect of triglyceride on plasma miR‐4286 (β coefficients: 0.27 [95% CI, 0.01–0.53] and 0.27 [95% CI, 0.07–0.47] separately by inverse variance‐weighted and Mendelian randomization‐pleiotropy residual sum and outlier tests). Moreover, the causal mediation analysis indicated that plasma miR‐4286 explained 5.5% (95% CI, 0.7%–17.0%) of the association of triglyceride with incident ACS. CONCLUSIONS: Higher level of plasma miR‐4286 was associated with an increased risk of ACS. The upregulated miR‐4286 in plasma can be attributed to higher triglyceride level and may mediate the effect of triglyceride on incident ACS. |
format | Online Article Text |
id | pubmed-8174203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81742032021-06-11 Prospective Study on Plasma MicroRNA‐4286 and Incident Acute Coronary Syndrome Shen, Miaoyan Xu, Xuedan Liu, Xuezhen Wang, Qiuhong Li, Wending You, Xiaomin Peng, Rong Yuan, Yu Long, Pinpin Niu, Rundong Yang, Handong Cheng, Xiang Pan, An Tanguay, Robert M. Zhang, Xiaomin He, Meian Wang, Chaolong Liang, Liming Wu, Tangchun J Am Heart Assoc Original Research BACKGROUND: Mounting evidence suggests that circulating microRNAs (miRNAs) are critical indicators of cardiovascular disease. However, prospective studies linking circulating miRNAs to incident acute coronary syndrome (ACS) are limited, and the underlying effect of associated miRNA on incident ACS remains unknown. METHODS AND RESULTS: Based on a 2‐stage prospective nested case–control design within the Dongfeng‐Tongji cohort, we profiled plasma miRNAs from 23 pairs of incident ACS cases and controls by microarray and validated the candidate miRNAs in 572 incident ACS case–control pairs using quantitative real‐time polymerase chain reaction. We observed that plasma miR‐4286 was associated with higher risk of ACS (adjusted odds ratio according to an interquartile range increase, 1.26 [95% CI, 1.07–1.48]). Further association analysis revealed that triglyceride was positively associated with plasma miR‐4286, and an interquartile range increase in triglyceride was associated with an 11.04% (95% CI, 3.77%–18.83%) increase in plasma miR‐4286. In addition, the Mendelian randomization analysis suggested a potential causal effect of triglyceride on plasma miR‐4286 (β coefficients: 0.27 [95% CI, 0.01–0.53] and 0.27 [95% CI, 0.07–0.47] separately by inverse variance‐weighted and Mendelian randomization‐pleiotropy residual sum and outlier tests). Moreover, the causal mediation analysis indicated that plasma miR‐4286 explained 5.5% (95% CI, 0.7%–17.0%) of the association of triglyceride with incident ACS. CONCLUSIONS: Higher level of plasma miR‐4286 was associated with an increased risk of ACS. The upregulated miR‐4286 in plasma can be attributed to higher triglyceride level and may mediate the effect of triglyceride on incident ACS. John Wiley and Sons Inc. 2021-03-10 /pmc/articles/PMC8174203/ /pubmed/33719498 http://dx.doi.org/10.1161/JAHA.120.018999 Text en © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Research Shen, Miaoyan Xu, Xuedan Liu, Xuezhen Wang, Qiuhong Li, Wending You, Xiaomin Peng, Rong Yuan, Yu Long, Pinpin Niu, Rundong Yang, Handong Cheng, Xiang Pan, An Tanguay, Robert M. Zhang, Xiaomin He, Meian Wang, Chaolong Liang, Liming Wu, Tangchun Prospective Study on Plasma MicroRNA‐4286 and Incident Acute Coronary Syndrome |
title | Prospective Study on Plasma MicroRNA‐4286 and Incident Acute Coronary Syndrome |
title_full | Prospective Study on Plasma MicroRNA‐4286 and Incident Acute Coronary Syndrome |
title_fullStr | Prospective Study on Plasma MicroRNA‐4286 and Incident Acute Coronary Syndrome |
title_full_unstemmed | Prospective Study on Plasma MicroRNA‐4286 and Incident Acute Coronary Syndrome |
title_short | Prospective Study on Plasma MicroRNA‐4286 and Incident Acute Coronary Syndrome |
title_sort | prospective study on plasma microrna‐4286 and incident acute coronary syndrome |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174203/ https://www.ncbi.nlm.nih.gov/pubmed/33719498 http://dx.doi.org/10.1161/JAHA.120.018999 |
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