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Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease

Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in the heart, providing support to the contracting myocardium and contributing to a myriad of physiological signaling processes. Despite the importance of fibrosis in processes of wound healing, excessiv...

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Detalles Bibliográficos
Autores principales: Hall, Caitlin, Gehmlich, Katja, Denning, Chris, Pavlovic, Davor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174279/
https://www.ncbi.nlm.nih.gov/pubmed/33586463
http://dx.doi.org/10.1161/JAHA.120.019338
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author Hall, Caitlin
Gehmlich, Katja
Denning, Chris
Pavlovic, Davor
author_facet Hall, Caitlin
Gehmlich, Katja
Denning, Chris
Pavlovic, Davor
author_sort Hall, Caitlin
collection PubMed
description Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in the heart, providing support to the contracting myocardium and contributing to a myriad of physiological signaling processes. Despite the importance of fibrosis in processes of wound healing, excessive fibroblast proliferation and activation can lead to pathological remodeling, driving heart failure and the onset of arrhythmias. Our understanding of the mechanisms driving the cardiac fibroblast activation and proliferation is expanding, and evidence for their direct and indirect effects on cardiac myocyte function is accumulating. In this review, we focus on the importance of the fibroblast‐to‐myofibroblast transition and the cross talk of cardiac fibroblasts with cardiac myocytes. We also consider the current use of models used to explore these questions.
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spelling pubmed-81742792021-06-11 Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease Hall, Caitlin Gehmlich, Katja Denning, Chris Pavlovic, Davor J Am Heart Assoc Contemporary Review Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in the heart, providing support to the contracting myocardium and contributing to a myriad of physiological signaling processes. Despite the importance of fibrosis in processes of wound healing, excessive fibroblast proliferation and activation can lead to pathological remodeling, driving heart failure and the onset of arrhythmias. Our understanding of the mechanisms driving the cardiac fibroblast activation and proliferation is expanding, and evidence for their direct and indirect effects on cardiac myocyte function is accumulating. In this review, we focus on the importance of the fibroblast‐to‐myofibroblast transition and the cross talk of cardiac fibroblasts with cardiac myocytes. We also consider the current use of models used to explore these questions. John Wiley and Sons Inc. 2021-02-15 /pmc/articles/PMC8174279/ /pubmed/33586463 http://dx.doi.org/10.1161/JAHA.120.019338 Text en © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Contemporary Review
Hall, Caitlin
Gehmlich, Katja
Denning, Chris
Pavlovic, Davor
Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease
title Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease
title_full Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease
title_fullStr Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease
title_full_unstemmed Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease
title_short Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease
title_sort complex relationship between cardiac fibroblasts and cardiomyocytes in health and disease
topic Contemporary Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174279/
https://www.ncbi.nlm.nih.gov/pubmed/33586463
http://dx.doi.org/10.1161/JAHA.120.019338
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