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Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study
BACKGROUND: Although Black adults are more likely to die from coronary heart disease (CHD) compared with White adults, few studies have examined the relationship between cigarette smoking and CHD risk among Black adults. We evaluated the relationship between cigarette smoking, incident CHD, and coro...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174312/ https://www.ncbi.nlm.nih.gov/pubmed/33754833 http://dx.doi.org/10.1161/JAHA.120.017320 |
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author | Oshunbade, Adebamike A. Kassahun‐Yimer, Wondwosen Valle, Karen A. Hamid, Arsalan Kipchumba, Rodney K. Kamimura, Daisuke Clark, Donald White, Wendy B. DeFilippis, Andrew P. Blaha, Michael J. Benjamin, Emelia J. O’Brien, Emily C. Mentz, Robert J. Rodriguez, Carlos J. Fox, Ervin R. Butler, Javed Keith, Rachel J. Bhatnagar, Aruni Marie Robertson, Rose Correa, Adolfo Hall, Michael E. |
author_facet | Oshunbade, Adebamike A. Kassahun‐Yimer, Wondwosen Valle, Karen A. Hamid, Arsalan Kipchumba, Rodney K. Kamimura, Daisuke Clark, Donald White, Wendy B. DeFilippis, Andrew P. Blaha, Michael J. Benjamin, Emelia J. O’Brien, Emily C. Mentz, Robert J. Rodriguez, Carlos J. Fox, Ervin R. Butler, Javed Keith, Rachel J. Bhatnagar, Aruni Marie Robertson, Rose Correa, Adolfo Hall, Michael E. |
author_sort | Oshunbade, Adebamike A. |
collection | PubMed |
description | BACKGROUND: Although Black adults are more likely to die from coronary heart disease (CHD) compared with White adults, few studies have examined the relationship between cigarette smoking and CHD risk among Black adults. We evaluated the relationship between cigarette smoking, incident CHD, and coronary artery calcification in the JHS (Jackson Heart Study). METHODS AND RESULTS: We classified JHS participants without a history of CHD (n=4432) by self‐reported baseline smoking status into current, former (smoked at least 400 cigarettes/life) or never smokers at baseline (2000–2004). We further classified current smokers by smoking intensity (number of cigarettes smoked per day [1–19 or ≥20]) and followed for incident CHD (through 2016). Hazard ratios (HR) for incident CHD for each smoking group compared with never smokers were estimated with adjusted Cox proportional hazard regression models. At baseline, there were 548 (12.4%) current, 782 (17.6%) former, and 3102 (70%) never smokers. During follow‐up (median, 13.8 years), 254 participants developed CHD. After risk factor adjustment, CHD risk was significantly higher in current smokers compared with never smokers (HR, 2.11; 95% CI, 1.39–3.18); the difference between former smokers and never smokers (HR, 1.37; 95% CI, 1.0–1.90) did not achieve statistical significance. Among current smokers, we did not observe a dose‐response effect for CHD risk. Additionally, in multivariable logistic regression models with a subset of our analytic cohort, current smokers had greater odds of coronary artery calcification score >0 compared with never smokers (odds ratio, 2.63; 95% CI, 1.88–3.68). CONCLUSIONS: In a large prospective cohort of Black adults, current smoking was associated with a >2‐fold increased risk of CHD over a median follow‐up of greater than a decade. |
format | Online Article Text |
id | pubmed-8174312 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81743122021-06-11 Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study Oshunbade, Adebamike A. Kassahun‐Yimer, Wondwosen Valle, Karen A. Hamid, Arsalan Kipchumba, Rodney K. Kamimura, Daisuke Clark, Donald White, Wendy B. DeFilippis, Andrew P. Blaha, Michael J. Benjamin, Emelia J. O’Brien, Emily C. Mentz, Robert J. Rodriguez, Carlos J. Fox, Ervin R. Butler, Javed Keith, Rachel J. Bhatnagar, Aruni Marie Robertson, Rose Correa, Adolfo Hall, Michael E. J Am Heart Assoc Original Research BACKGROUND: Although Black adults are more likely to die from coronary heart disease (CHD) compared with White adults, few studies have examined the relationship between cigarette smoking and CHD risk among Black adults. We evaluated the relationship between cigarette smoking, incident CHD, and coronary artery calcification in the JHS (Jackson Heart Study). METHODS AND RESULTS: We classified JHS participants without a history of CHD (n=4432) by self‐reported baseline smoking status into current, former (smoked at least 400 cigarettes/life) or never smokers at baseline (2000–2004). We further classified current smokers by smoking intensity (number of cigarettes smoked per day [1–19 or ≥20]) and followed for incident CHD (through 2016). Hazard ratios (HR) for incident CHD for each smoking group compared with never smokers were estimated with adjusted Cox proportional hazard regression models. At baseline, there were 548 (12.4%) current, 782 (17.6%) former, and 3102 (70%) never smokers. During follow‐up (median, 13.8 years), 254 participants developed CHD. After risk factor adjustment, CHD risk was significantly higher in current smokers compared with never smokers (HR, 2.11; 95% CI, 1.39–3.18); the difference between former smokers and never smokers (HR, 1.37; 95% CI, 1.0–1.90) did not achieve statistical significance. Among current smokers, we did not observe a dose‐response effect for CHD risk. Additionally, in multivariable logistic regression models with a subset of our analytic cohort, current smokers had greater odds of coronary artery calcification score >0 compared with never smokers (odds ratio, 2.63; 95% CI, 1.88–3.68). CONCLUSIONS: In a large prospective cohort of Black adults, current smoking was associated with a >2‐fold increased risk of CHD over a median follow‐up of greater than a decade. John Wiley and Sons Inc. 2021-03-23 /pmc/articles/PMC8174312/ /pubmed/33754833 http://dx.doi.org/10.1161/JAHA.120.017320 Text en © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Research Oshunbade, Adebamike A. Kassahun‐Yimer, Wondwosen Valle, Karen A. Hamid, Arsalan Kipchumba, Rodney K. Kamimura, Daisuke Clark, Donald White, Wendy B. DeFilippis, Andrew P. Blaha, Michael J. Benjamin, Emelia J. O’Brien, Emily C. Mentz, Robert J. Rodriguez, Carlos J. Fox, Ervin R. Butler, Javed Keith, Rachel J. Bhatnagar, Aruni Marie Robertson, Rose Correa, Adolfo Hall, Michael E. Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study |
title | Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study |
title_full | Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study |
title_fullStr | Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study |
title_full_unstemmed | Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study |
title_short | Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study |
title_sort | cigarette smoking, incident coronary heart disease, and coronary artery calcification in black adults: the jackson heart study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174312/ https://www.ncbi.nlm.nih.gov/pubmed/33754833 http://dx.doi.org/10.1161/JAHA.120.017320 |
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