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Longitudinal Associations of Fitness and Obesity in Young Adulthood With Right Ventricular Function and Pulmonary Artery Systolic Pressure in Middle Age: The CARDIA Study

BACKGROUND: Low cardiorespiratory fitness (CRF) and obesity are risk factors for heart failure but their associations with right ventricular (RV) systolic function and pulmonary artery systolic pressure (PASP) are not well understood. METHODS AND RESULTS: Participants in the CARDIA (Coronary Artery...

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Autores principales: Patel, Kershaw V., Metzinger, Mark, Park, Bryan, Allen, Norrina, Ayers, Colby, Kawut, Steven M., Sidney, Stephen, Goff, David C., Jacobs, David R., Zaky, Ahmed F., Carnethon, Mercedes, Berry, Jarett D., Pandey, Ambarish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174339/
https://www.ncbi.nlm.nih.gov/pubmed/33775106
http://dx.doi.org/10.1161/JAHA.120.016968
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author Patel, Kershaw V.
Metzinger, Mark
Park, Bryan
Allen, Norrina
Ayers, Colby
Kawut, Steven M.
Sidney, Stephen
Goff, David C.
Jacobs, David R.
Zaky, Ahmed F.
Carnethon, Mercedes
Berry, Jarett D.
Pandey, Ambarish
author_facet Patel, Kershaw V.
Metzinger, Mark
Park, Bryan
Allen, Norrina
Ayers, Colby
Kawut, Steven M.
Sidney, Stephen
Goff, David C.
Jacobs, David R.
Zaky, Ahmed F.
Carnethon, Mercedes
Berry, Jarett D.
Pandey, Ambarish
author_sort Patel, Kershaw V.
collection PubMed
description BACKGROUND: Low cardiorespiratory fitness (CRF) and obesity are risk factors for heart failure but their associations with right ventricular (RV) systolic function and pulmonary artery systolic pressure (PASP) are not well understood. METHODS AND RESULTS: Participants in the CARDIA (Coronary Artery Risk Development in Young Adults) study who underwent maximal treadmill testing at baseline and had a follow‐up echocardiographic examination at year 25 were included. A subset of participants had repeat CRF and body mass index (BMI) assessment at year 20. The associations of baseline and changes in CRF and BMI on follow‐up (baseline to year 20) with RV systolic function parameters (tricuspid annular plane systolic excursion, RV Doppler systolic velocity of the lateral tricuspid annulus), and PASP were assessed using multivariable‐adjusted linear regression models. The study included 3433 participants. In adjusted analysis, higher baseline BMI but not CRF was significantly associated with higher PASP. Among RV systolic function parameters, higher baseline CRF and BMI were significantly associated with higher tricuspid annular plane systolic excursion and RV systolic velocity of the lateral tricuspid annulus. In the subgroup of participants with follow‐up assessment of CRF or BMI at year 20, less decline in CRF was associated with higher RV systolic velocity of the lateral tricuspid annulus and lower PASP, while greater increase in BMI was significantly associated with higher PASP in middle age. CONCLUSIONS: Higher CRF in young adulthood and less decline in CRF over time are each significantly associated with better RV systolic function. Higher baseline BMI and greater age‐related increases in BMI are each significantly associated with higher PASP in middle age. These findings provide insights into possible mechanisms through which low fitness and obesity may contribute toward risk of heart failure.
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spelling pubmed-81743392021-06-11 Longitudinal Associations of Fitness and Obesity in Young Adulthood With Right Ventricular Function and Pulmonary Artery Systolic Pressure in Middle Age: The CARDIA Study Patel, Kershaw V. Metzinger, Mark Park, Bryan Allen, Norrina Ayers, Colby Kawut, Steven M. Sidney, Stephen Goff, David C. Jacobs, David R. Zaky, Ahmed F. Carnethon, Mercedes Berry, Jarett D. Pandey, Ambarish J Am Heart Assoc Original Research BACKGROUND: Low cardiorespiratory fitness (CRF) and obesity are risk factors for heart failure but their associations with right ventricular (RV) systolic function and pulmonary artery systolic pressure (PASP) are not well understood. METHODS AND RESULTS: Participants in the CARDIA (Coronary Artery Risk Development in Young Adults) study who underwent maximal treadmill testing at baseline and had a follow‐up echocardiographic examination at year 25 were included. A subset of participants had repeat CRF and body mass index (BMI) assessment at year 20. The associations of baseline and changes in CRF and BMI on follow‐up (baseline to year 20) with RV systolic function parameters (tricuspid annular plane systolic excursion, RV Doppler systolic velocity of the lateral tricuspid annulus), and PASP were assessed using multivariable‐adjusted linear regression models. The study included 3433 participants. In adjusted analysis, higher baseline BMI but not CRF was significantly associated with higher PASP. Among RV systolic function parameters, higher baseline CRF and BMI were significantly associated with higher tricuspid annular plane systolic excursion and RV systolic velocity of the lateral tricuspid annulus. In the subgroup of participants with follow‐up assessment of CRF or BMI at year 20, less decline in CRF was associated with higher RV systolic velocity of the lateral tricuspid annulus and lower PASP, while greater increase in BMI was significantly associated with higher PASP in middle age. CONCLUSIONS: Higher CRF in young adulthood and less decline in CRF over time are each significantly associated with better RV systolic function. Higher baseline BMI and greater age‐related increases in BMI are each significantly associated with higher PASP in middle age. These findings provide insights into possible mechanisms through which low fitness and obesity may contribute toward risk of heart failure. John Wiley and Sons Inc. 2021-03-28 /pmc/articles/PMC8174339/ /pubmed/33775106 http://dx.doi.org/10.1161/JAHA.120.016968 Text en © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Patel, Kershaw V.
Metzinger, Mark
Park, Bryan
Allen, Norrina
Ayers, Colby
Kawut, Steven M.
Sidney, Stephen
Goff, David C.
Jacobs, David R.
Zaky, Ahmed F.
Carnethon, Mercedes
Berry, Jarett D.
Pandey, Ambarish
Longitudinal Associations of Fitness and Obesity in Young Adulthood With Right Ventricular Function and Pulmonary Artery Systolic Pressure in Middle Age: The CARDIA Study
title Longitudinal Associations of Fitness and Obesity in Young Adulthood With Right Ventricular Function and Pulmonary Artery Systolic Pressure in Middle Age: The CARDIA Study
title_full Longitudinal Associations of Fitness and Obesity in Young Adulthood With Right Ventricular Function and Pulmonary Artery Systolic Pressure in Middle Age: The CARDIA Study
title_fullStr Longitudinal Associations of Fitness and Obesity in Young Adulthood With Right Ventricular Function and Pulmonary Artery Systolic Pressure in Middle Age: The CARDIA Study
title_full_unstemmed Longitudinal Associations of Fitness and Obesity in Young Adulthood With Right Ventricular Function and Pulmonary Artery Systolic Pressure in Middle Age: The CARDIA Study
title_short Longitudinal Associations of Fitness and Obesity in Young Adulthood With Right Ventricular Function and Pulmonary Artery Systolic Pressure in Middle Age: The CARDIA Study
title_sort longitudinal associations of fitness and obesity in young adulthood with right ventricular function and pulmonary artery systolic pressure in middle age: the cardia study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174339/
https://www.ncbi.nlm.nih.gov/pubmed/33775106
http://dx.doi.org/10.1161/JAHA.120.016968
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