Cargando…

Extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury

Hypercalcaemia due to immobilisation is an uncommon diagnosis and requires extensive evaluation to rule out common causes of hypercalcaemia such as primary hyperparathyroidism and malignancy. We report an unusual case of profound hypercalcaemia due to immobilisation in a young man due to acute spina...

Descripción completa

Detalles Bibliográficos
Autores principales: Tettero, Jesse Marc, van Eeghen, Elmer, Kooter, Albertus Jozef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174501/
https://www.ncbi.nlm.nih.gov/pubmed/34083190
http://dx.doi.org/10.1136/bcr-2020-241386
_version_ 1783702922203234304
author Tettero, Jesse Marc
van Eeghen, Elmer
Kooter, Albertus Jozef
author_facet Tettero, Jesse Marc
van Eeghen, Elmer
Kooter, Albertus Jozef
author_sort Tettero, Jesse Marc
collection PubMed
description Hypercalcaemia due to immobilisation is an uncommon diagnosis and requires extensive evaluation to rule out common causes of hypercalcaemia such as primary hyperparathyroidism and malignancy. We report an unusual case of profound hypercalcaemia due to immobilisation in a young man due to acute spinal cord ischaemia, leading to paraplegia. Other causes of hypercalcaemia were ruled out and elevated bone turnover markers supported our hypothesis. Conventional treatment with intravenous fluids, bisphosphonates and diuretics was insufficient. Subcutaneous calcitonin lowered the plasma calcium acutely and was continued for 8 weeks. Subsequent normocalcaemia was sustained for 2 years.
format Online
Article
Text
id pubmed-8174501
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-81745012021-06-17 Extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury Tettero, Jesse Marc van Eeghen, Elmer Kooter, Albertus Jozef BMJ Case Rep Case Report Hypercalcaemia due to immobilisation is an uncommon diagnosis and requires extensive evaluation to rule out common causes of hypercalcaemia such as primary hyperparathyroidism and malignancy. We report an unusual case of profound hypercalcaemia due to immobilisation in a young man due to acute spinal cord ischaemia, leading to paraplegia. Other causes of hypercalcaemia were ruled out and elevated bone turnover markers supported our hypothesis. Conventional treatment with intravenous fluids, bisphosphonates and diuretics was insufficient. Subcutaneous calcitonin lowered the plasma calcium acutely and was continued for 8 weeks. Subsequent normocalcaemia was sustained for 2 years. BMJ Publishing Group 2021-06-02 /pmc/articles/PMC8174501/ /pubmed/34083190 http://dx.doi.org/10.1136/bcr-2020-241386 Text en © BMJ Publishing Group Limited 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Case Report
Tettero, Jesse Marc
van Eeghen, Elmer
Kooter, Albertus Jozef
Extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury
title Extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury
title_full Extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury
title_fullStr Extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury
title_full_unstemmed Extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury
title_short Extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury
title_sort extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174501/
https://www.ncbi.nlm.nih.gov/pubmed/34083190
http://dx.doi.org/10.1136/bcr-2020-241386
work_keys_str_mv AT tetterojessemarc extremehypercalcaemiacausedbyimmobilisationduetoacutespinalcordinjury
AT vaneeghenelmer extremehypercalcaemiacausedbyimmobilisationduetoacutespinalcordinjury
AT kooteralbertusjozef extremehypercalcaemiacausedbyimmobilisationduetoacutespinalcordinjury