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Extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury
Hypercalcaemia due to immobilisation is an uncommon diagnosis and requires extensive evaluation to rule out common causes of hypercalcaemia such as primary hyperparathyroidism and malignancy. We report an unusual case of profound hypercalcaemia due to immobilisation in a young man due to acute spina...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174501/ https://www.ncbi.nlm.nih.gov/pubmed/34083190 http://dx.doi.org/10.1136/bcr-2020-241386 |
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author | Tettero, Jesse Marc van Eeghen, Elmer Kooter, Albertus Jozef |
author_facet | Tettero, Jesse Marc van Eeghen, Elmer Kooter, Albertus Jozef |
author_sort | Tettero, Jesse Marc |
collection | PubMed |
description | Hypercalcaemia due to immobilisation is an uncommon diagnosis and requires extensive evaluation to rule out common causes of hypercalcaemia such as primary hyperparathyroidism and malignancy. We report an unusual case of profound hypercalcaemia due to immobilisation in a young man due to acute spinal cord ischaemia, leading to paraplegia. Other causes of hypercalcaemia were ruled out and elevated bone turnover markers supported our hypothesis. Conventional treatment with intravenous fluids, bisphosphonates and diuretics was insufficient. Subcutaneous calcitonin lowered the plasma calcium acutely and was continued for 8 weeks. Subsequent normocalcaemia was sustained for 2 years. |
format | Online Article Text |
id | pubmed-8174501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-81745012021-06-17 Extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury Tettero, Jesse Marc van Eeghen, Elmer Kooter, Albertus Jozef BMJ Case Rep Case Report Hypercalcaemia due to immobilisation is an uncommon diagnosis and requires extensive evaluation to rule out common causes of hypercalcaemia such as primary hyperparathyroidism and malignancy. We report an unusual case of profound hypercalcaemia due to immobilisation in a young man due to acute spinal cord ischaemia, leading to paraplegia. Other causes of hypercalcaemia were ruled out and elevated bone turnover markers supported our hypothesis. Conventional treatment with intravenous fluids, bisphosphonates and diuretics was insufficient. Subcutaneous calcitonin lowered the plasma calcium acutely and was continued for 8 weeks. Subsequent normocalcaemia was sustained for 2 years. BMJ Publishing Group 2021-06-02 /pmc/articles/PMC8174501/ /pubmed/34083190 http://dx.doi.org/10.1136/bcr-2020-241386 Text en © BMJ Publishing Group Limited 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Case Report Tettero, Jesse Marc van Eeghen, Elmer Kooter, Albertus Jozef Extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury |
title | Extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury |
title_full | Extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury |
title_fullStr | Extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury |
title_full_unstemmed | Extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury |
title_short | Extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury |
title_sort | extreme hypercalcaemia caused by immobilisation due to acute spinal cord injury |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174501/ https://www.ncbi.nlm.nih.gov/pubmed/34083190 http://dx.doi.org/10.1136/bcr-2020-241386 |
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