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Glibenclamide does not improve outcome following severe collagenase-induced intracerebral hemorrhage in rats

Intracerebral hemorrhage (ICH) is a devastating insult with few effective treatments. Edema and raised intracranial pressure contribute to poor outcome after ICH. Glibenclamide blocks the sulfonylurea 1 transient receptor potential melastatin 4 (Sur1-Trpm4) channel implicated in edema formation. Whi...

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Detalles Bibliográficos
Autores principales:	Kung, Tiffany F. C., Wilkinson, Cassandra M., Dirks, Christine A., Jickling, Glen C., Colbourne, Frederick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174736/ https://www.ncbi.nlm.nih.gov/pubmed/34081746 http://dx.doi.org/10.1371/journal.pone.0252584

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