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Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis

Macrophages destroy pathogens and diseased cells through Fcγ receptor (FcγR)-driven phagocytosis of antibody-opsonized targets. Phagocytosis requires activation of multiple FcγRs, but the mechanism controlling the threshold for response is unclear. We developed a DNA origami-based engulfment system...

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Detalles Bibliográficos
Autores principales:	Kern, Nadja, Dong, Rui, Douglas, Shawn M, Vale, Ronald D, Morrissey, Meghan A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175083/ https://www.ncbi.nlm.nih.gov/pubmed/34080973 http://dx.doi.org/10.7554/eLife.68311

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