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Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis

Innate lymphoid cells (ILCs) are the most recently discovered family of innate immune cells. ILCs can be categorized into three groups on the basis of the transcription factors that direct their functions and the cytokines they produce. Notably, these functions parallel the effector functions of T l...

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Detalles Bibliográficos
Autores principales: Kim, Jihyun, Ryu, Seungwon, Kim, Hye Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175152/
https://www.ncbi.nlm.nih.gov/pubmed/33972473
http://dx.doi.org/10.14348/molcells.2021.0053
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author Kim, Jihyun
Ryu, Seungwon
Kim, Hye Young
author_facet Kim, Jihyun
Ryu, Seungwon
Kim, Hye Young
author_sort Kim, Jihyun
collection PubMed
description Innate lymphoid cells (ILCs) are the most recently discovered family of innate immune cells. ILCs can be categorized into three groups on the basis of the transcription factors that direct their functions and the cytokines they produce. Notably, these functions parallel the effector functions of T lymphocytes. ILCs play a frontline role in host defense and tissue homeostasis by responding rapidly to environmental factors, conducting effector responses in a tissue-specific manner, and interacting with hematopoietic and non-hematopoietic cells throughout the body. Moreover, recent studies reveal that ILCs are involved in development of various inflammatory diseases, such as respiratory diseases, autoimmune diseases, or cancer. In this review, we discuss the recent findings regarding the biology of ILCs in health and inflammatory diseases.
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spelling pubmed-81751522021-06-14 Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis Kim, Jihyun Ryu, Seungwon Kim, Hye Young Mol Cells Minireview Innate lymphoid cells (ILCs) are the most recently discovered family of innate immune cells. ILCs can be categorized into three groups on the basis of the transcription factors that direct their functions and the cytokines they produce. Notably, these functions parallel the effector functions of T lymphocytes. ILCs play a frontline role in host defense and tissue homeostasis by responding rapidly to environmental factors, conducting effector responses in a tissue-specific manner, and interacting with hematopoietic and non-hematopoietic cells throughout the body. Moreover, recent studies reveal that ILCs are involved in development of various inflammatory diseases, such as respiratory diseases, autoimmune diseases, or cancer. In this review, we discuss the recent findings regarding the biology of ILCs in health and inflammatory diseases. Korean Society for Molecular and Cellular Biology 2021-05-31 2021-05-11 /pmc/articles/PMC8175152/ /pubmed/33972473 http://dx.doi.org/10.14348/molcells.2021.0053 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. https://creativecommons.org/licenses/by-nc-sa/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ (https://creativecommons.org/licenses/by-nc-sa/3.0/)
spellingShingle Minireview
Kim, Jihyun
Ryu, Seungwon
Kim, Hye Young
Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis
title Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis
title_full Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis
title_fullStr Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis
title_full_unstemmed Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis
title_short Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis
title_sort innate lymphoid cells in tissue homeostasis and disease pathogenesis
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175152/
https://www.ncbi.nlm.nih.gov/pubmed/33972473
http://dx.doi.org/10.14348/molcells.2021.0053
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