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Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis
Innate lymphoid cells (ILCs) are the most recently discovered family of innate immune cells. ILCs can be categorized into three groups on the basis of the transcription factors that direct their functions and the cytokines they produce. Notably, these functions parallel the effector functions of T l...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Molecular and Cellular Biology
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175152/ https://www.ncbi.nlm.nih.gov/pubmed/33972473 http://dx.doi.org/10.14348/molcells.2021.0053 |
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author | Kim, Jihyun Ryu, Seungwon Kim, Hye Young |
author_facet | Kim, Jihyun Ryu, Seungwon Kim, Hye Young |
author_sort | Kim, Jihyun |
collection | PubMed |
description | Innate lymphoid cells (ILCs) are the most recently discovered family of innate immune cells. ILCs can be categorized into three groups on the basis of the transcription factors that direct their functions and the cytokines they produce. Notably, these functions parallel the effector functions of T lymphocytes. ILCs play a frontline role in host defense and tissue homeostasis by responding rapidly to environmental factors, conducting effector responses in a tissue-specific manner, and interacting with hematopoietic and non-hematopoietic cells throughout the body. Moreover, recent studies reveal that ILCs are involved in development of various inflammatory diseases, such as respiratory diseases, autoimmune diseases, or cancer. In this review, we discuss the recent findings regarding the biology of ILCs in health and inflammatory diseases. |
format | Online Article Text |
id | pubmed-8175152 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean Society for Molecular and Cellular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-81751522021-06-14 Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis Kim, Jihyun Ryu, Seungwon Kim, Hye Young Mol Cells Minireview Innate lymphoid cells (ILCs) are the most recently discovered family of innate immune cells. ILCs can be categorized into three groups on the basis of the transcription factors that direct their functions and the cytokines they produce. Notably, these functions parallel the effector functions of T lymphocytes. ILCs play a frontline role in host defense and tissue homeostasis by responding rapidly to environmental factors, conducting effector responses in a tissue-specific manner, and interacting with hematopoietic and non-hematopoietic cells throughout the body. Moreover, recent studies reveal that ILCs are involved in development of various inflammatory diseases, such as respiratory diseases, autoimmune diseases, or cancer. In this review, we discuss the recent findings regarding the biology of ILCs in health and inflammatory diseases. Korean Society for Molecular and Cellular Biology 2021-05-31 2021-05-11 /pmc/articles/PMC8175152/ /pubmed/33972473 http://dx.doi.org/10.14348/molcells.2021.0053 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. https://creativecommons.org/licenses/by-nc-sa/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ (https://creativecommons.org/licenses/by-nc-sa/3.0/) |
spellingShingle | Minireview Kim, Jihyun Ryu, Seungwon Kim, Hye Young Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis |
title | Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis |
title_full | Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis |
title_fullStr | Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis |
title_full_unstemmed | Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis |
title_short | Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis |
title_sort | innate lymphoid cells in tissue homeostasis and disease pathogenesis |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175152/ https://www.ncbi.nlm.nih.gov/pubmed/33972473 http://dx.doi.org/10.14348/molcells.2021.0053 |
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