Cargando…

Roles of lysine-specific demethylase 1 (LSD1) in homeostasis and diseases

Lysine-specific demethylase 1 (LSD1) targets mono- or di-methylated histone H3K4 and H3K9 as well as non-histone substrates and functions in the regulation of gene expression as a transcriptional repressor or activator. This enzyme plays a pivotal role in various physiological processes, including d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Dongha, Kim, Keun Il, Baek, Sung Hee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175190/ https://www.ncbi.nlm.nih.gov/pubmed/34082769 http://dx.doi.org/10.1186/s12929-021-00737-3

Ejemplares similares

Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer
por: Majello, Barbara, et al.
Publicado: (2019)

Lysine-specific histone demethylase 1A (LSD1) in cervical cancer
por: Beilner, Daniel, et al.
Publicado: (2020)

Lysine-Specific Demethylase 1 (LSD1) epigenetically controls osteoblast differentiation
por: Rummukainen, Petri, et al.
Publicado: (2022)

Novel spirocyclic tranylcypromine derivatives as lysine-specific demethylase 1 (LSD1) inhibitors
por: Shi, Ying, et al.
Publicado: (2018)

Lysine-Specific Demethylase 1 (LSD1/KDM1A) Inhibition as a Target for Disease Modification in Myelofibrosis
por: Gill, Harinder
Publicado: (2022)

The Catalytic-Dependent and -Independent Roles of Lsd1 and Lsd2 Lysine Demethylases in Heterochromatin Formation in Schizosaccharomyces pombe
por: Marayati, Bahjat F., et al.
Publicado: (2020)

Lysine-Specific Demethylase 1 (LSD1)-Mediated Epigenetic Modification of Immunogenicity and Immunomodulatory Effects in Breast Cancers
por: Lee, Dong Yeul, et al.
Publicado: (2023)

Catalytic Mechanism Investigation of Lysine-Specific Demethylase 1 (LSD1): A Computational Study
por: Kong, Xiangqian, et al.
Publicado: (2011)

Lysine-specific demethylase 1 (LSD1) destabilizes p62 and inhibits autophagy in gynecologic malignancies
por: Chao, Angel, et al.
Publicado: (2017)

Lysine-specific demethylase LSD1 regulates autophagy in neuroblastoma through SESN2-dependent pathway
por: Ambrosio, S, et al.
Publicado: (2017)

The Epigenetic Controller Lysine-Specific Demethylase 1 (LSD1) Regulates the Outcome of Hepatitis C Viral Infection
por: Papadopoulou, Georgia, et al.
Publicado: (2023)

Lysine-Specific Demethylase 1 (LSD1) Is Required for the Transcriptional Repression of the Telomerase Reverse Transcriptase (hTERT) Gene
por: Zhu, Qingjun, et al.
Publicado: (2008)

Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma
por: Amente, Stefano, et al.
Publicado: (2015)

Functional characterization of lysine-specific demethylase 2 (LSD2/KDM1B) in breast cancer progression
por: Chen, Lin, et al.
Publicado: (2017)

Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines
por: Konovalov, Sergiy, et al.
Publicado: (2013)

OR04-3 Lysine-Specific Demethylase-1 (LSD1) Deficiency Increases Aldosterone Signaling via Mineralocorticoid Receptor Activation
por: Treesaranuwattana, Thitinan, et al.
Publicado: (2019)

Functional Interaction of Histone Deacetylase 5 (HDAC5) and Lysine-specific Demethylase 1 (LSD1) Promotes Breast Cancer Progression
por: Cao, Chunyu, et al.
Publicado: (2016)

Nitroreductase‐Mediated Release of Inhibitors of Lysine‐Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells
por: Herrlinger, Eva‐Maria, et al.
Publicado: (2020)

Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes
por: Padalino, Gilda, et al.
Publicado: (2023)

Inhibition of lysine-specific demethylase 1 (LSD1) prevented tumor growth and metastasis by downregulating PD-L1 expression in lung adenocarcinoma
por: He, Pengxing, et al.
Publicado: (2022)

Elevated expression of LSD1 (Lysine-specific demethylase 1) during tumour progression from pre-invasive to invasive ductal carcinoma of the breast
por: Serce, Nuran, et al.
Publicado: (2012)

Tranylcypromine, a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis
por: Sun, Qunyan, et al.
Publicado: (2016)

Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni
por: Coutinho Carneiro, Vitor, et al.
Publicado: (2020)

Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines
por: Welch, Darcy, et al.
Publicado: (2019)

Activation of HIV Transcription by the Viral Tat Protein Requires a Demethylation Step Mediated by Lysine-specific Demethylase 1 (LSD1/KDM1)
por: Sakane, Naoki, et al.
Publicado: (2011)

Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase 1 (LSD1/KDM1A)
por: Li, Zhonghua, et al.
Publicado: (2019)

Regulation of HIF-1α stability by lysine methylation
por: Baek, Sung Hee, et al.
Publicado: (2016)

Histone demethylase LSD1 controls the phenotypic plasticity of cancer cells
por: Hino, Shinjiro, et al.
Publicado: (2016)

Targeting lysine-specific demethylase 1 (KDM1A/LSD1) impairs colorectal cancer tumorigenesis by affecting cancer cells stemness, motility, and differentiation
por: Antona, Annamaria, et al.
Publicado: (2023)

Targeting Histone Demethylase LSD1/KDM1a in Neurodegenerative Diseases
por: Ambrosio, Susanna, et al.
Publicado: (2018)

Correction: Gill, H. Lysine-Specific Demethylase 1 (LSD1/KDM1A) Inhibition as a Target for Disease Modification in Myelofibrosis. Cells 2022, 11, 2107
por: Gill, Harinder
Publicado: (2022)

Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition
por: Zeng, Cheng, et al.
Publicado: (2023)

Lysine-Specific Demethylase 1 (LSD1) Inhibitor S2101 Induces Autophagy via the AKT/mTOR Pathway in SKOV3 Ovarian Cancer Cells
por: Feng, Shujun, et al.
Publicado: (2016)

Inhibition of LSD1 phosphorylation alleviates colitis symptoms induced by dextran sulfate sodium
por: Oh, Chaeyoon, et al.
Publicado: (2020)

Inhibition of Lysine-Specific Demethylase-1 (LSD1/KDM1A) Promotes the Adipogenic Differentiation of hESCs Through H3K4 Methylation
por: Xiong, Yujing, et al.
Publicado: (2016)

LSD1: more than demethylation of histone lysine residues
por: Perillo, Bruno, et al.
Publicado: (2020)

GSK-LSD1, an LSD1 inhibitor, quashes SARS-CoV-2-triggered cytokine release syndrome in-vitro
por: Hong, Kyung Soo, et al.
Publicado: (2020)

The histone demethylase LSD1/KDM1A promotes the DNA damage response
por: Mosammaparast, Nima, et al.
Publicado: (2013)

A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1
por: Prusevich, Polina, et al.
Publicado: (2014)

Splicing- and demethylase-independent functions of LSD1 in zebrafish primitive hematopoiesis
por: Tamaoki, Junya, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5it1c98vcnoiu5m2g0iopdejk1