Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma

Despite the development of new targeted and immune therapies, the prognosis of metastatic melanoma remains bleak. Therefore, it is critical to better understand the mechanisms controlling advanced melanoma to develop more effective treatment regimens. Hedgehog/GLI (HH/GLI) signaling inhibitors targe...

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Detalles Bibliográficos
Autores principales: Pietrobono, Silvia, Gaudio, Eugenio, Gagliardi, Sinforosa, Zitani, Mariapaola, Carrassa, Laura, Migliorini, Francesca, Petricci, Elena, Manetti, Fabrizio, Makukhin, Nikolai, Bond, Adam G., Paradise, Brooke D., Ciulli, Alessio, Fernandez-Zapico, Martin E., Bertoni, Francesco, Stecca, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175236/
https://www.ncbi.nlm.nih.gov/pubmed/33958721
http://dx.doi.org/10.1038/s41388-021-01783-9

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