Integrase-derived peptides together with CD24-targeted lentiviral particles inhibit the growth of CD24 expressing cancer cells

The integration of viral DNA into the host genome is mediated by viral integrase, resulting in the accumulation of double-strand breaks. Integrase-derived peptides (INS and INR) increase the number of integration events, leading to escalated genomic instability that induces apoptosis. CD24 is a surf...

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Detalles Bibliográficos
Autores principales: Shapira, Shiran, Finkelshtein, Eynat, Kazanov, Dina, Naftali, Esmira, Stepansky, Irena, Loyter, Abraham, Elbirt, Daniel, Hay-Levy, Mori, Brazowski, Eli, Bedny, Faina, Dekel, Roy, Hershkovitz, Dov, Blachar, Arye, Wolf, Ido, Arber, Nadir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175240/
https://www.ncbi.nlm.nih.gov/pubmed/33958722
http://dx.doi.org/10.1038/s41388-021-01779-5

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