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Burden of Uncontrolled Hyperglycemia and Its Association with Patients Characteristics and Socioeconomic Status in Philadelphia, USA

Purpose: To examine the burden of uncontrolled hyperglycemia in patients with diabetes mellitus (DM) and their characteristics in a large urban city. Methods: A randomized sample of 4993 patients with DM ≥18 years old who received routine health care in a large university teaching hospital in the ci...

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Autores principales: Liu, Longjian, Wang, Fengge, Gracely, Edward J., Moore, Kari, Melly, Steven, Zhang, Fengqing, Sato, Priscila Y., Eisen, Howard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175259/
https://www.ncbi.nlm.nih.gov/pubmed/34095699
http://dx.doi.org/10.1089/heq.2020.0076
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author Liu, Longjian
Wang, Fengge
Gracely, Edward J.
Moore, Kari
Melly, Steven
Zhang, Fengqing
Sato, Priscila Y.
Eisen, Howard J.
author_facet Liu, Longjian
Wang, Fengge
Gracely, Edward J.
Moore, Kari
Melly, Steven
Zhang, Fengqing
Sato, Priscila Y.
Eisen, Howard J.
author_sort Liu, Longjian
collection PubMed
description Purpose: To examine the burden of uncontrolled hyperglycemia in patients with diabetes mellitus (DM) and their characteristics in a large urban city. Methods: A randomized sample of 4993 patients with DM ≥18 years old who received routine health care in a large university teaching hospital in the city of Philadelphia was analyzed. Uncontrolled hyperglycemia was classified as blood hemoglobin A1c >8%. The associations of uncontrolled hyperglycemia with sociodemographic and cardiovascular factors were analyzed using univariate and multivariate analysis methods. Results: The results show that patients 18–54 years had the highest prevalence of uncontrolled hyperglycemia (36.0%), followed by those at age 55–64 (30.9%), 65–74 (22.9%), and ≥75 (20.6%) years (p<0.0001). Unadjusted hyperglycemia was significantly associated with patients with increased total cholesterol to high-density lipoprotein ratio (odds ratio [OR]=1.59, 95% confidence interval [CI]: 1.33–1.90, p<0.001), and with prevalent coronary heart disease (OR=1.39, 95% CI: 1.16–1.67, p=0.001). Patients living in neighborhoods with lower socioeconomic status (SES) had significantly higher uncontrolled hyperglycemia rates across the city (r=0.52, R(2)=0.27, p=0.03). Conclusions: Findings of this study is one of the first studies to address that younger adults had higher rates of uncontrolled hyperglycemia. Further attention should be paid to the challenges of controlling DM in younger adults and patients who live in neighborhoods with lower SES.
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spelling pubmed-81752592021-06-04 Burden of Uncontrolled Hyperglycemia and Its Association with Patients Characteristics and Socioeconomic Status in Philadelphia, USA Liu, Longjian Wang, Fengge Gracely, Edward J. Moore, Kari Melly, Steven Zhang, Fengqing Sato, Priscila Y. Eisen, Howard J. Health Equity Original Article Purpose: To examine the burden of uncontrolled hyperglycemia in patients with diabetes mellitus (DM) and their characteristics in a large urban city. Methods: A randomized sample of 4993 patients with DM ≥18 years old who received routine health care in a large university teaching hospital in the city of Philadelphia was analyzed. Uncontrolled hyperglycemia was classified as blood hemoglobin A1c >8%. The associations of uncontrolled hyperglycemia with sociodemographic and cardiovascular factors were analyzed using univariate and multivariate analysis methods. Results: The results show that patients 18–54 years had the highest prevalence of uncontrolled hyperglycemia (36.0%), followed by those at age 55–64 (30.9%), 65–74 (22.9%), and ≥75 (20.6%) years (p<0.0001). Unadjusted hyperglycemia was significantly associated with patients with increased total cholesterol to high-density lipoprotein ratio (odds ratio [OR]=1.59, 95% confidence interval [CI]: 1.33–1.90, p<0.001), and with prevalent coronary heart disease (OR=1.39, 95% CI: 1.16–1.67, p=0.001). Patients living in neighborhoods with lower socioeconomic status (SES) had significantly higher uncontrolled hyperglycemia rates across the city (r=0.52, R(2)=0.27, p=0.03). Conclusions: Findings of this study is one of the first studies to address that younger adults had higher rates of uncontrolled hyperglycemia. Further attention should be paid to the challenges of controlling DM in younger adults and patients who live in neighborhoods with lower SES. Mary Ann Liebert, Inc., publishers 2020-12-30 /pmc/articles/PMC8175259/ /pubmed/34095699 http://dx.doi.org/10.1089/heq.2020.0076 Text en © Longjian Liu et al., 2020; Published by Mary Ann Liebert, Inc. https://creativecommons.org/licenses/by/4.0/This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Liu, Longjian
Wang, Fengge
Gracely, Edward J.
Moore, Kari
Melly, Steven
Zhang, Fengqing
Sato, Priscila Y.
Eisen, Howard J.
Burden of Uncontrolled Hyperglycemia and Its Association with Patients Characteristics and Socioeconomic Status in Philadelphia, USA
title Burden of Uncontrolled Hyperglycemia and Its Association with Patients Characteristics and Socioeconomic Status in Philadelphia, USA
title_full Burden of Uncontrolled Hyperglycemia and Its Association with Patients Characteristics and Socioeconomic Status in Philadelphia, USA
title_fullStr Burden of Uncontrolled Hyperglycemia and Its Association with Patients Characteristics and Socioeconomic Status in Philadelphia, USA
title_full_unstemmed Burden of Uncontrolled Hyperglycemia and Its Association with Patients Characteristics and Socioeconomic Status in Philadelphia, USA
title_short Burden of Uncontrolled Hyperglycemia and Its Association with Patients Characteristics and Socioeconomic Status in Philadelphia, USA
title_sort burden of uncontrolled hyperglycemia and its association with patients characteristics and socioeconomic status in philadelphia, usa
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175259/
https://www.ncbi.nlm.nih.gov/pubmed/34095699
http://dx.doi.org/10.1089/heq.2020.0076
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