In vitro assessment and phase I randomized clinical trial of anfibatide a snake venom derived anti-thrombotic agent targeting human platelet GPIbα

The interaction of platelet GPIbα with von Willebrand factor (VWF) is essential to initiate platelet adhesion and thrombosis, particularly under high shear stress conditions. However, no drug targeting GPIbα has been developed for clinical practice. Here we characterized anfibatide, a GPIbα antagoni...

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Detalles Bibliográficos
Autores principales: Li, Benjamin Xiaoyi, Dai, Xiangrong, Xu, Xiaohong Ruby, Adili, Reheman, Neves, Miguel Antonio Dias, Lei, Xi, Shen, Chuanbin, Zhu, Guangheng, Wang, Yiming, Zhou, Hui, Hou, Yan, Ni, Tiffany, Pasman, Yfke, Yang, Zhongqiang, Qian, Fang, Zhao, Yanan, Gao, Yongxiang, Liu, Jing, Teng, Maikun, Marshall, Alexandra H., Cerenzia, Eric G., Li, Mandy Lokyee, Ni, Heyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175443/
https://www.ncbi.nlm.nih.gov/pubmed/34083615
http://dx.doi.org/10.1038/s41598-021-91165-8

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