3D architecture and structural flexibility revealed in the subfamily of large glutamate dehydrogenases by a mycobacterial enzyme

Glutamate dehydrogenases (GDHs) are widespread metabolic enzymes that play key roles in nitrogen homeostasis. Large glutamate dehydrogenases composed of 180 kDa subunits (L-GDHs(180)) contain long N- and C-terminal segments flanking the catalytic core. Despite the relevance of L-GDHs(180) in bacteri...

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Detalles Bibliográficos
Autores principales: Lázaro, Melisa, Melero, Roberto, Huet, Charlotte, López-Alonso, Jorge P., Delgado, Sandra, Dodu, Alexandra, Bruch, Eduardo M., Abriata, Luciano A., Alzari, Pedro M., Valle, Mikel, Lisa, María-Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175468/
https://www.ncbi.nlm.nih.gov/pubmed/34083757
http://dx.doi.org/10.1038/s42003-021-02222-x

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