Transformation of SOX9(+) cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma

SOX9 (Sex-determining region Y Box 9) is a well-characterized transcription factor that is a marker for progenitor cells in various tissues. In the liver, cells delineated by SOX9 are responsible for regenerating liver parenchyma when cell proliferation is impaired following chronic injury. However,...

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Detalles Bibliográficos
Autores principales: Chen, Jingyu, Debebe, Anketse, Zeng, Ni, Kopp, Janel, He, Lina, Sander, Maike, Stiles, Bangyan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175600/
https://www.ncbi.nlm.nih.gov/pubmed/34083580
http://dx.doi.org/10.1038/s41598-021-90958-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175600/
https://www.ncbi.nlm.nih.gov/pubmed/34083580
http://dx.doi.org/10.1038/s41598-021-90958-1

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