Cargando…

The curcumin analog (PAC) suppressed cell survival and induced apoptosis and autophagy in oral cancer cells

PAC (3,5-Bis (4-hydroxy-3-methoxybenzylidene)-N-methyl-4-piperidone), a novel bioactive curcumin analog, has been reported to have anticancer properties against various tumors. However, the anti-cancer effects of PAC on oral cavity squamous cell carcinoma were not studied yet. Our aim is to investig...

Descripción completa

Detalles Bibliográficos
Autores principales:	Semlali, Abdelhabib, Contant, Camille, Al-Otaibi, Basem, Al-Jammaz, Ibrahim, Chandad, Fatiha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175612/ https://www.ncbi.nlm.nih.gov/pubmed/34083581 http://dx.doi.org/10.1038/s41598-021-90754-x

Ejemplares similares

Anethole induces anti-oral cancer activity by triggering apoptosis, autophagy and oxidative stress and by modulation of multiple signaling pathways
por: Contant, Camille, et al.
Publicado: (2021)

Synergistic Effects of New Curcumin Analog (PAC) and Cisplatin on Oral Cancer Therapy
por: Semlali, Abdelhabib, et al.
Publicado: (2023)

The curcumin analogue PAC has potent anti-anaplastic thyroid cancer effects
por: Al-Mohanna, Mai, et al.
Publicado: (2023)

The Curcumin Analog PAC Is a Potential Solution for the Treatment of Triple-Negative Breast Cancer by Modulating the Gene Expression of DNA Repair Pathways
por: Almalki, Esraa, et al.
Publicado: (2023)

PAC down-regulates estrogen receptor alpha and suppresses epithelial-to-mesenchymal transition in breast cancer cells
por: Al-Howail, Huda A., et al.
Publicado: (2016)

Rapamycin inhibits oral cancer cell growth by promoting oxidative stress and suppressing ERK1/2, NF-κB and beta-catenin pathways
por: Semlali, Abdelhabib, et al.
Publicado: (2022)

Development of new copper-64 labeled rhodamine: a potential PET myocardial perfusion imaging agent
por: AlHokbany, Norah, et al.
Publicado: (2022)

Radioiodinated Naphthylalanine Derivatives Targeting Pancreatic Beta Cells in Normal and Nonobese Diabetic Mice
por: Amartey, John K., et al.
Publicado: (2008)

Oxidative Stress and Autophagy Mediate Anti-Cancer Properties of Cannabis Derivatives in Human Oral Cancer Cells
por: Loubaki, Lionel, et al.
Publicado: (2022)

Sarcocystis camelicanis increases interleukin (IL)-6 expression in one-humped camels (Camelus dromedarius) from Riyadh and Al Qassim, Saudi Arabia
por: Metwally, Dina M., et al.
Publicado: (2021)

Editorial: Targeting redox regulation and autophagy systems for cancer therapy
por: Zhang, Junmin, et al.
Publicado: (2023)

Curcumin suppresses AGEs induced apoptosis in tubular epithelial cells via protective autophagy
por: Wei, Ying, et al.
Publicado: (2017)

Autophagy and Apoptosis in Hepatocellular Carcinoma Induced by EF25-(GSH)(2): A Novel Curcumin Analog
por: Zhou, Tao, et al.
Publicado: (2014)

Curcumin induces apoptosis and autophagy inhuman renal cell carcinoma cells via Akt/mTOR suppression
por: Gong, Xuelian, et al.
Publicado: (2021)

Cannabinoid Mixture Affects the Fate and Functions of B Cells through the Modulation of the Caspase and MAP Kinase Pathways
por: Lampron, Marie-Claude, et al.
Publicado: (2023)

Synergistic Effect of Anethole and Platinum Drug Cisplatin against Oral Cancer Cell Growth and Migration by Inhibiting MAPKase, Beta-Catenin, and NF-κB Pathways
por: Semlali, Abdelhabib, et al.
Publicado: (2023)

Disruption of the ECM33 Gene in Candida albicans Prevents Biofilm Formation, Engineered Human Oral Mucosa Tissue Damage and Gingival Cell Necrosis/Apoptosis
por: Rouabhia, Mahmoud, et al.
Publicado: (2012)

E-Cigarettes Increase Candida albicans Growth and Modulate its Interaction with Gingival Epithelial Cells
por: Alanazi, Humidah, et al.
Publicado: (2019)

Whole Cigarette Smoke Increased the Expression of TLRs, HBDs, and Proinflammory Cytokines by Human Gingival Epithelial Cells through Different Signaling Pathways
por: Semlali, Abdelhabib, et al.
Publicado: (2012)

Fast Fluorine-18 labeling and preclinical evaluation of novel Mucin1 and its Folate hybrid peptide conjugate for targeting breast carcinoma
por: Al Jammaz, I., et al.
Publicado: (2021)

Curcumin Induces Autophagy, Apoptosis, and Cell Cycle Arrest in Human Pancreatic Cancer Cells
por: Zhu, Yaping, et al.
Publicado: (2017)

Sodium-22-radiolabeled silica nanoparticles as new radiotracer for biomedical applications: in vivo positron emission tomography imaging, biodistribution, and biocompatibility
por: Al Faraj, Achraf, et al.
Publicado: (2015)

The Synthetic Curcumin Analog HO-3867 Rescues Suppression of PLAC1 Expression in Ovarian Cancer Cells
por: Devor, Eric J., et al.
Publicado: (2021)

Barriers and Enablers to Implementing Teledentistry From the Perspective of Dental Health Care Professionals: Protocol for a Systematic Quantitative, Qualitative, and Mixed Studies Review
por: Kengne Talla, Pascaline, et al.
Publicado: (2023)

Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation
por: Rainey, Nathan E., et al.
Publicado: (2019)

In Vivo and In Vitro Suppression of Hepatocellular Carcinoma by EF24, a Curcumin Analog
por: Liu, Haitao, et al.
Publicado: (2012)

JNK pathway mediates curcumin-induced apoptosis and autophagy in osteosarcoma MG63 cells
por: Zhang, Yaowu, et al.
Publicado: (2017)

Hydroxyethyl Starch Curcumin Enhances Antiproliferative Effect of Curcumin Against HepG2 Cells via Apoptosis and Autophagy Induction
por: Jiang, Linhai, et al.
Publicado: (2021)

Cigarette Smoke-Exposed Candida albicans Increased Chitin Production and Modulated Human Fibroblast Cell Responses
por: Alanazi, Humidah, et al.
Publicado: (2014)

A convenient and efficient total solid-phase synthesis of DOTA-functionalized tumor-targeting peptides for PET imaging of cancer
por: Okarvi, Subhani M., et al.
Publicado: (2019)

Development of the Tumor-Specific Antigen-Derived Synthetic Peptides as Potential Candidates for Targeting Breast and Other Possible Human Carcinomas
por: Okarvi, Subhani M., et al.
Publicado: (2019)

Curcumin Analog DK1 Induces Apoptosis in Human Osteosarcoma Cells In Vitro through Mitochondria-Dependent Signaling Pathway
por: Aziz, Muhammad Nazirul Mubin, et al.
Publicado: (2018)

Antischistosomal and anti-inflammatory activity of garlic and allicin compared with that of praziquantel in vivo
por: Metwally, Dina M., et al.
Publicado: (2018)

Two SNPs in the promoter region of Toll-like receptor 4 gene are not associated with smoking in Saudi Arabia
por: Kohailan, Muhammad, et al.
Publicado: (2017)

PAC in FACTT: Time to PAC it in?
por: Mansour, Wissam, et al.
Publicado: (2008)

Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27
por: Silva, Gabriel, et al.
Publicado: (2018)

Inhibition of HIV-1 by curcumin A, a novel curcumin analog
por: Kumari, Namita, et al.
Publicado: (2015)

Structurally Modified Curcumin Analogs Inhibit STAT3 Phosphorylation and Promote Apoptosis of Human Renal Cell Carcinoma and Melanoma Cell Lines
por: Bill, Matthew A., et al.
Publicado: (2012)

Curcumin and Novel Synthetic Analogs in Cell-Based Studies of Alzheimer’s Disease
por: Gagliardi, Stella, et al.
Publicado: (2018)

Selective Targeting of Cancer Cells by Oxidative Vulnerabilities with Novel Curcumin Analogs
por: Pignanelli, Christopher, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_rtldeqbmsbmooa4m5jbaj1v4nq